Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weiss, TW; Rohla, M; Dieplinger, B; Domanovits, H; Fries, D; Vosko, MR; Gary, T; Ay, C.
[Edoxaban for stroke prevention in atrial fibrillation and treatment of venous thromboembolism: an expert position paper].
Wien Med Wochenschr. 2018; 168(5-6):133-143
Doi: 10.1007/s10354-017-0548-4
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- Co-Autor*innen der Med Uni Graz
- Gary Thomas
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- Abstract:
- Edoxaban is the most recent available representative of the Non-Vitamin K antagonist oral anticoagulants (NOAC). The approval was based on the largest phase III trials of NOACs for stroke prevention in patients with non-valvular atrial fibrillation (AF, ENGAGE-AF), and for the treatment of venous thromboembolism (VTE, HOKUSAI-VTE). In both trials, edoxaban was associated with similar efficacy and a significant reduction in bleeding events with respect to the pre-defined primary safety endpoints, as compared to warfarin.Additionally, the once daily dosing of edoxaban, the clinically investigated strategy for dose-reduction based on clearly defined criteria and the favorable pharmacokinetic profile might further support the clinical applicability of the substance.In the light of recent data, this expert consensus document aims to summarize the latest clinical trial results while providing a concise overview of current guideline recommendations on the management of patients with non-valvular AF and VTE.
- Find related publications in this database (Keywords)
- Edoxaban
- Non-Vitamin K antagonist oral anticoagulants
- Atrial fibrillation
- Venous thromboembolism