Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kratochvílová, S; Škoch, A; Wohl, P; Švehlíková, E; Dezortová, M; Hill, M; Hájek, M; Pelikánová, T.
Intramyocellular lipid content in subjects with impaired fasting glucose after telmisartan treatment, a randomised cross-over trial.
Magn Reson Imaging. 2016; 34(3): 353-358.
Doi: 10.1016/j.mri.2015.10.031
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Svehlikova Eva
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- Abstract:
- Ectopic lipid accumulation in skeletal muscle is associated with insulin resistance. Telmisartan improves metabolic parameters in type 2 diabetic patients. The aim of our study was to evaluate the in vivo effect of telmisartan on intramyocellular lipid content (IMCL) in subjects with impaired fasting glucose (IFG) by magnetic resonance spectroscopy (MRS). We enrolled 10 subjects with IFG in a cross-over, placebo-controlled, randomized, double-blind trial, treated with 3 weeks of telmisartan (160 mg daily) or placebo. After completing each treatment, a hyperinsulinaemic euglycaemic clamp (1 mU/kg per min; 5 mmol/l; 120 min) to assess insulin action (metabolic clearance rate of glucose, MCR) and (1)H MRS of the m. tibialis anterior using a MR Scanner Siemens Vision operating at 1.5 T to evaluate IMCL content, were performed. Plasma adipokine levels were determined simultaneously. Telmisartan treatment resulted in a lower fasting plasma glucose (FPG) (p < 0.05), but insulin action was comparable to after placebo. Telmisartan did not affect IMCL content. After placebo, IMCL correlated negatively with total cholesterol (p < 0.001), MCR (p < 0.05) and adiponectin (p < 0.05) and positively with FPG (p < 0.05). After telmisartan treatment there was only a positive correlation between IMCL and TNFα (p < 0.05). IMCL content is related to parameters of glucose metabolism and insulin action in sedentary IFG subjects. A short telmisartan treatment did not affect the IMCL content despite its positive effect on FPG. The improvement in FPG was probably mediated through interference with other metabolic pathways. Copyright © 2015 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipokines - blood
- Adiponectin - blood
- Adiponectin - chemistry
- Adult -
- Benzimidazoles - therapeutic use
- Benzoates - therapeutic use
- Blood Glucose - chemistry
- Calorimetry -
- Cholesterol - chemistry
- Cross-Over Studies -
- Cytoplasm - metabolism
- Double-Blind Method -
- Glucose Clamp Technique -
- Humans -
- Insulin - chemistry
- Insulin Resistance -
- Lipids - chemistry
- Magnetic Resonance Spectroscopy -
- Male -
- Metabolic Syndrome X - blood
- Middle Aged -
- Muscles - metabolism
- Find related publications in this database (Keywords)
- Telmisartan
- Insulin resistance
- H-1 MR Spectroscopy
- Intramyocellular lipid content
- Impaired fasting glucose