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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kratochvílová, S; Skoch, A; Dezortová, M; Svehlíková, E; Hill, M; Brunová, J; Hájek, M; Pelikánová, T.
Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy--a pilot study.
Physiol Res. 2014; 63(4): 513-519.
Doi: 10.33549/physiolres.932505
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- Co-authors Med Uni Graz
- Svehlikova Eva
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- Abstract:
- To determine whether acutely-induced supraphysiological hyperinsulinemia influences brain metabolism in patients with type 1 diabetes (D) and healthy controls (C) as detected by MR Spectroscopy. Group D consisted of 4 patients with the average duration of diabetes for 7 years. They were matched according to age, sex and BMI to 4 healthy controls. 1H MR Spectroscopy was performed with a 1.5 Tesla. Spectra were obtained from parietooccipital white matter repeatedly during a 3-h hyperinsulinemic euglycemic clamp with 2 mU.kg(-1).min(-1). In group D, significantly lower basal concentrations of N-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to C. After the induction of hyperinsulinemia, concentrations of choline, creatine, GABA, inositol, lactate, NAA and composite signal glutamate + glutamine (Glx) stayed stable. The detection of glucose signal is less realiable at 1.5 Tesla but we registered the alteration in glucose concentration (p=0.003) in the whole group. Originally sightly elevated glucose concentration in D decreased on the contrary to the increase of originally lower glucose level in C. In conclusions, brain metabolism was altered in D. Short term supraphysiological euglycemic hyperinsulinemia induced changes in the concentration of brain glucose in both C and D.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amino Acids - analysis
- Amino Acids - metabolism
- Blood Glucose - analysis
- Brain Chemistry -
- Diabetes Mellitus, Type 1 - metabolism
- Female -
- Glucose Clamp Technique -
- Humans -
- Hyperinsulinism - metabolism
- Magnetic Resonance Spectroscopy -
- Male -
- Pilot Projects -
- Young Adult -
- Find related publications in this database (Keywords)
- Brain glucose metabolism
- Hyperinsulinemic clamp
- Magnetic resonance spectroscopy
- Type 1 diabetes