Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wree, A; Mix, E; Hawlitschka, A; Antipova, V; Witt, M; Schmitt, O; Benecke, R.
Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease.
Neurobiol Dis. 2011; 41(2): 291-298.
Doi: 10.1016/j.nbd.2010.09.017
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Antipova Veronica Alexandra
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced cholinergic hyperactivity prevails in the striatum. Interruption of acetylcholine (ACh) release in the striatum by locally injected botulinum neurotoxin A (BoNT-A) has been studied in the rat 6-hydroxydopamine (6-OHDA) model of PD (hemi-PD). The hemi-PD was induced by injection of 6-OHDA into the right medial forebrain bundle. Motor dysfunction provoked by apomorphine-induced contralateral rotation was completely reversed for more than 3 months by ipsilateral intrastriatal application of 1-2 ng BoNT-A. Interestingly, BoNT-A injected alone into the right striatum of naïve rats caused a slight transient ipsilateral apomorphine-induced rotation, which lasted only for about one month. Immunohistochemically, large axonal swellings appeared within the striatum injected with BoNT-A, which we tentatively named BoNT-A-induced varicosities. They contained either choline acetyltransferase or tyrosine hydroxylase. These findings suggest a selective inhibition of evoked release of ACh by locally applied BoNT-A. Intrastriatal application of BoNT-A may antagonize localized relative functional disinhibited hypercholinergic activity in neurodegenerative diseases such as PD avoiding side effects of systemic anti-cholinergic treatment. Copyright © 2010 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Axons - pathology
- Axons - physiology
- Botulinum Toxins, Type A - therapeutic use
- Corpus Striatum - drug effects
- Corpus Striatum - pathology
- Corpus Striatum - physiopathology
- Disease Models, Animal -
- Dyskinesias - drug therapy
- Dyskinesias - pathology
- Dyskinesias - physiopathology
- Growth Cones - drug effects
- Growth Cones - pathology
- Growth Cones - ultrastructure
- Male -
- Nerve Regeneration - drug effects
- Nerve Regeneration - physiology
- Neurotoxins - therapeutic use
- Oxidopamine - toxicity
- Parkinsonian Disorders - drug therapy
- Parkinsonian Disorders - etiology
- Parkinsonian Disorders - pathology
- Rats -
- Rats, Wistar -
- Rotation - adverse effects
- Find related publications in this database (Keywords)
- Botulinum neurotoxin A
- 6-Hydroxy dopamine
- Striatum
- Motor function
- Apomorphine-induced rotation
- Axonal varicosities