Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzmann, C; Dräger, D; Mix, E; Hawlitschka, A; Antipova, V; Benecke, R; Wree, A.
Effects of intrastriatal botulinum neurotoxin A on the behavior of Wistar rats.
Behav Brain Res. 2012; 234(1): 107-116.
Doi: 10.1016/j.bbr.2012.06.008
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Antipova Veronica Alexandra
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- Abstract:
- Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed interaction of dopaminergic and cholinergic circuits. In Parkinson's disease imbalanced cholinergic hyperactivity prevails in the striatum. As recently shown intrastiatal botulinum neurotoxin A (BoNT-A) improves motor function in hemiparkinsonian rats. Before going further steps in using intracerebral BoNT-injections as possible treatment we here explore whether pure BoNT-injections into normal rats' striata affect their cognitive and emotional properties. Wistar rats were injected bilaterally with 1 ng BoNT-A or vehicle (sham injection) into the striatum, whereas a naïve control group was left untreated. Locomotor activity, balance and coordination were assessed in open field and accelerod tests. Anxiety was evaluated in the open field and elevated plus maze. Spatial learning was assessed by radial and water maze tests. Intrastriatal BoNT-A, but also sham injections caused decreased motor activity and impaired balance and motor coordination of rats. Slight working memory deficits were observed in radial maze testing of both BoNT-A and sham injected animals arguing for a consequence of surgery rather than for a specific BoNT-A effect. In contrast, BoNT-A injected animals showed a reduced anxiety in open field and elevated plus maze compared to both sham-treated and naïve controls. As bilateral intrastriatal BoNT-A injections in normal rats do not cause cognitive impairments and reduce anxiety, and previous findings showed improvements of motor function in hemiparkinsonian rats following intrastriatal BoNT-A, it can be argued that intrastriatal BoNT-A could be a new therapeutic approach in Parkinson's disease. Copyright © 2012 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anxiety - drug therapy
- Anxiety - physiopathology
- Behavior, Animal - drug effects
- Botulinum Toxins, Type A - pharmacology
- Botulinum Toxins, Type A - therapeutic use
- Corpus Striatum - drug effects
- Disease Models, Animal -
- Male -
- Maze Learning - drug effects
- Memory - drug effects
- Motor Activity - drug effects
- Parkinson Disease - drug therapy
- Parkinson Disease - physiopathology
- Rats -
- Rats, Wistar -
- Find related publications in this database (Keywords)
- Behavior
- BoNT-A
- Rat
- Cognition
- Striatum
- Motor function