Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dschietzig, TB; Boschann, F; Ruppert, J; Armbruster, FP; Meinitzer, A; Bankovic, D; Mitrovic, V; Melzer, C.
Plasma Zonulin and its Association with Kidney Function, Severity of Heart Failure, and Metabolic Inflammation.
CLIN LAB. 2016; 62(12): 2443-2447.
Doi: 10.7754/Clin.Lab.2016.160512
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- Co-Autor*innen der Med Uni Graz
- Meinitzer Andreas
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- Abstract:
- The tight junction regulator zonulin has attracted clinical attention as a biomarker of increased gastrointestinal permeability. Recent work also suggests zonulin to represent a general regulator of tissue barriers and a player in metabolic inflammation. Here, we investigated the associations of zonulin with chronic heart failure (CHF), kidney function, and metabolic inflammation. Using multiple linear regression (Generalized Linear Model), this study determined the association of plasma zonulin with different laboratory and clinical parameters in 225 patients carrying automatic implantable cardioverters/defibrillators (AICD) for primary or secondary prevention. In another 115 patients with diastolic or systolic CHF, we investigated a possible relationship between zonulin and CHF severity. In the AICD cohort, zonulin associated inversely with serum creatinine (p = 0.013), carboxymethyl-lysine calprotectin (p < 0.001), and kynurenine (p = 0.009) and positively with homoarginine (p < 0.001). In the subgroup with type-2 diabetes (T2D) (n = 51), zonulin increased significantly with high-sensitivity CRP (p = 0.014). In the CHF cohort, we found a highly significant rise of NT-proBNP, but not of zonulin with NYHA functional classes I-IV or other parameters of CHF severity. The inverse associations of zonulin with creatinine and markers of cardio-vascular risk (high CMLcalprotectin and kynurenine, low homoarginine) are novel findings that need further experimental and clinical clarification. Our study indicates zonulin involvement in metabolic inflammation in T2D, but no association with disease status in CHF.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Cholera Toxin - blood
- Female -
- Heart Failure - blood
- Heart Failure - diagnosis
- Heart Failure - therapy
- Humans -
- Inflammation - blood
- Inflammation - diagnosis
- Kidney - physiopathology
- Kidney Diseases - blood
- Kidney Diseases - diagnosis
- Kidney Diseases - physiopathology
- Linear Models -
- Male -
- Metabolic Diseases - blood
- Metabolic Diseases - diagnosis
- Middle Aged -
- Predictive Value of Tests -
- Prognosis -
- Severity of Illness Index -
- Find related publications in this database (Keywords)
- zonulin
- tight junctions
- heart failure
- chronic kidney disease
- diabetes