Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reich, O; Regauer, S.
Thin HSIL of the Cervix: Detecting a Variant of High-grade Squamous Intraepithelial Lesions With a p16INK4a Antibody.
Int J Gynecol Pathol. 2017; 36(1):71-75
Doi: 10.1097/PGP.0000000000000311
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Reich Olaf
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
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- Abstract:
- The WHO defines thin high-grade squamous intraepithelial lesions (HSIL) as a high-grade intraepithelial lesion of the cervix that is usually ≤9 cells thick. These lesions usually develop in early metaplastic squamous epithelium without anteceding low-grade squamous intraepithelial lesions (LSIL). The prevalence of thin HSIL is not well documented. We evaluated different characteristics of thin HSIL at time of treatment. We studied 25 formalin-fixed and paraffin-embedded conization specimens processed as step-serial sections. HSIL≤9 cells thick were classified as thin HSIL. HSIL≥10 cells thick were classified as classic HSIL. Immunohistochemical p16 staining was used to confirm lesions of thin HSIL. Overall, 19 (76%) specimens contained both thin HSIL and classic HSIL, 4 (16%) contained thin HSIL only, 1 (4%) contained classic-type HSIL only, and 1 (4%) contained thin HSIL and LSIL. Thin HSILs developed in both the columnar surface epithelium and deep cervical glandular epithelium. Most thin HSILs were 5 cells thick. All HSILs (thin and classic) were located inside the transformation zone and had a median horizontal extension of 8 mm (range, 0.3 to 21 mm). Our findings suggest that thin HSILs are frequent findings, that they coexist with classic HSIL, and preferably arise in the exposed parts of the transformation zone including the glandular crypts.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies -
- Cervical Intraepithelial Neoplasia - diagnosis
- Cervical Intraepithelial Neoplasia - metabolism
- Cervical Intraepithelial Neoplasia - pathology
- Cervix Uteri - metabolism
- Cervix Uteri - pathology
- Cyclin-Dependent Kinase Inhibitor p16 - metabolism
- Female -
- Humans -
- Middle Aged -
- Squamous Intraepithelial Lesions of the Cervix - diagnosis
- Squamous Intraepithelial Lesions of the Cervix - metabolism
- Squamous Intraepithelial Lesions of the Cervix - pathology
- Uterine Cervical Neoplasms - diagnosis
- Uterine Cervical Neoplasms - metabolism
- Uterine Cervical Neoplasms - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- Cervix
- Carcinogenesis
- Thin High-grade squamous Intraepithelial Lesions