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Resch, B; Egger, B; Kurath-Koller, S; Urlesberger, B.
Respiratory syncytial virus hospitalizations in infants of 28 weeks gestational age and less in the palivizumab era.
Int J Infect Dis. 2017; 57(6):50-53
Doi: 10.1016/j.ijid.2017.01.034
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- Leading authors Med Uni Graz
- Resch Bernhard
- Co-authors Med Uni Graz
- Kurath-Koller Stefan
- Urlesberger Berndt
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- Abstract:
- To obtain data on respiratory syncytial virus (RSV) associated hospitalization rates in preterm infants of 28 weeks gestational age and less in the era of palivizumab prophylaxis. Retrospective single-center cohort study including all preterm infants up to 28 weeks+6days gestational age and born between 2004 and 2012 at a tertiary care university hospital. Data on RSV related hospitalizations over the first two years of life covering at least two RSV seasons (November-April) were analyzed. Ninety-one of 287 (32%) infants were hospitalized due to respiratory illness, and a total of 17 infants (5.9%) tested RSV positive during the first 2 years of life. Fourteen infants (4.9%) were hospitalized during the first RSV season. RSV hospitalization rate in infants with BPD was 4.5% (2/44) compared to 4.9% (12/243) without BPD. Palivizumab prophylaxis was documented in 74.6% of the infants. Infants with RSV compared to other respiratory tract infection were of younger age (6.8 vs. 9.1 months; p=0.049), had longer hospital stays (median 11 vs. 5 days; p=0.043) and more severe respiratory illness (median LRI score 3 vs. 2; p=0.043). Despite palivizumab prophylaxis the burden of RSV disease and all cause respiratory illness was still remarkable in this vulnerable preterm population and mainly limited to the first season. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antiviral Agents - therapeutic use
- Cohort Studies -
- Female -
- Gestational Age -
- Hospitalization -
- Humans -
- Infant, Extremely Premature -
- Infant, Newborn -
- Male -
- Palivizumab - therapeutic use
- Respiratory Syncytial Virus Infections - drug therapy
- Respiratory Syncytial Virus Infections - epidemiology
- Respiratory Syncytial Virus, Human -
- Retrospective Studies -
- Find related publications in this database (Keywords)
- bronchopulmonary dysplasia
- palivizumab
- preterm infant
- respiratory syncytial virus
- respiratory tract infection