Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weissinger, EM; Human, C; Metzger, J; Hambach, L; Wolf, D; Greinix, HT; Dickinson, AM; Mullen, W; Jonigk, D; Kuzmina, Z; Kreipe, H; Schweier, P; Böhm, O; Türüchanow, I; Ihlenburg-Schwarz, D; Raad, J; Durban, A; Schiemann, M; Könecke, C; Diedrich, H; Holler, E; Beutel, G; Krauter, J; Ganser, A; Stadler, M.
The proteome pattern cGvHD_MS14 allows early and accurate prediction of chronic GvHD after allogeneic stem cell transplantation.
Leukemia. 2017; 31(3):654-662
Doi: 10.1038/leu.2016.259
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be curative, but is associated with significant morbidity and mortality. Chronic graft-versus-host disease (cGvHD), characterized by inflammation and fibrosis of multiple target organs, considerably contributes to the morbidity and mortality even years after allo-HSCT. Diagnosis of cGvHD is based on clinical features and histology of biopsies. Here, we report the generation of a urinary cGvHD-specific proteome-pattern (cGvHD_MS14) established by capillary electrophoresis-mass spectrometry to predict onset and severity of cGvHD as an unbiased laboratory test. cGvHD_MS14 was evaluated on samples from 412 patients collected prospectively in four transplant centers. Sensitivity and specificity was 84 and 76% by cGvHD_MS14 classification. Sensitivity further increased to 93% by combination of cGvHD_MS14 with relevant clinical variables to a logistic regression model. cGvHD was predicted up to 55 days prior to clinical diagnosis. Acute GvHD is not recognized by cGvHD_MS14. cGvHD_MS14 consists of 14 differentially excreted peptides, six of those have been sequenced to date and are fragments from thymosin β-4, eukaryotic translation initiation factor 4γ2, fibrinogen β-chain or collagens. In conclusion, the cGvHD_MS14-pattern allows early, highly sensitive and specific prediction of cGvHD as an independent diagnostic criterion of clinical diagnosis potentially allowing early therapeutic intervention.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Chronic Disease -
- Cluster Analysis -
- Cohort Studies -
- Female -
- Graft vs Host Disease - diagnosis
- Graft vs Host Disease - etiology
- Graft vs Host Disease - metabolism
- Graft vs Host Disease - prevention & control
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans -
- Incidence -
- Male -
- Middle Aged -
- Odds Ratio -
- Peptides - metabolism
- Proteome -
- Proteomics - methods
- ROC Curve -
- Reproducibility of Results -
- Severity of Illness Index -
- Transplantation, Homologous -
- Young Adult -