Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hibar, DP; Adams, HHH; Jahanshad, N; Chauhan, G; Stein, JL; Hofer, E; Renteria, ME; Bis, JC; Arias-Vasquez, A; Ikram, MK; Desrivières, S; Vernooij, MW; Abramovic, L; Alhusaini, S; Amin, N; Andersson, M; Arfanakis, K; Aribisala, BS; Armstrong, NJ; Athanasiu, L; Axelsson, T; Beecham, AH; Beiser, A; Bernard, M; Blanton, SH; Bohlken, MM; Boks, MP; Bralten, J; Brickman, AM; Carmichael, O; Chakravarty, MM; Chen, Q; Ching, CRK; Chouraki, V; Cuellar-Partida, G; Crivello, F; Den Braber, A; Doan, NT; Ehrlich, S; Giddaluru, S; Goldman, AL; Gottesman, RF; Grimm, O; Griswold, ME; Guadalupe, T; Gutman, BA; Hass, J; Haukvik, UK; Hoehn, D; Holmes, AJ; Hoogman, M; Janowitz, D; Jia, T; Jørgensen, KN; Karbalai, N; Kasperaviciute, D; Kim, S; Klein, M; Kraemer, B; Lee, PH; Liewald, DCM; Lopez, LM; Luciano, M; Macare, C; Marquand, AF; Matarin, M; Mather, KA; Mattheisen, M; McKay, DR; Milaneschi, Y; Muñoz Maniega, S; Nho, K; Nugent, AC; Nyquist, P; Loohuis, LMO; Oosterlaan, J; Papmeyer, M; Pirpamer, L; Pütz, B; Ramasamy, A; Richards, JS; Risacher, SL; Roiz-Santiañez, R; Rommelse, N; Ropele, S; Rose, EJ; Royle, NA; Rundek, T; Sämann, PG; Saremi, A; Satizabal, CL; Schmaal, L; Schork, AJ; Shen, L; Shin, J; Shumskaya, E; Smith, AV; Sprooten, E; Strike, LT; Teumer, A; Tordesillas-Gutierrez, D; Toro, R; Trabzuni, D; Trompet, S; Vaidya, D; Van der Grond, J; Van der Lee, SJ; Van der Meer, D; Van Donkelaar, MMJ; Van Eijk, KR; Van Erp, TGM; Van Rooij, D; Walton, E; Westlye, LT; Whelan, CD; Windham, BG; Winkler, AM; Wittfeld, K; Woldehawariat, G; Wolf, C; Wolfers, T; Yanek, LR; Yang, J; Zijdenbos, A; Zwiers, MP; Agartz, I; Almasy, L; Ames, D; Amouyel, P; Andreassen, OA; Arepalli, S; Assareh, AA; Barral, S; Bastin, ME; Becker, DM; Becker, JT; Bennett, DA; Blangero, J; van Bokhoven, H; Boomsma, DI; Brodaty, H; Brouwer, RM; Brunner, HG; Buckner, RL; Buitelaar, JK; Bulayeva, KB; Cahn, W; Calhoun, VD; Cannon, DM; Cavalleri, GL; Cheng, CY; Cichon, S; Cookson, MR; Corvin, A; Crespo-Facorro, B; Curran, JE; Czisch, M; Dale, AM; Davies, GE; De Craen, AJM; De Geus, EJC; De Jager, PL; De Zubicaray, GI; Deary, IJ; Debette, S; DeCarli, C; Delanty, N; Depondt, C; DeStefano, A; Dillman, A; Djurovic, S; Donohoe, G; Drevets, WC; Duggirala, R; Dyer, TD; Enzinger, C; Erk, S; Espeseth, T; Fedko, IO; Fernández, G; Ferrucci, L; Fisher, SE; Fleischman, DA; Ford, I; Fornage, M; Foroud, TM; Fox, PT; Francks, C; Fukunaga, M; Gibbs, JR; Glahn, DC; Gollub, RL; Göring, HHH; Green, RC; Gruber, O; Gudnason, V; Guelfi, S; Håberg, AK; Hansell, NK; Hardy, J; Hartman, CA; Hashimoto, R; Hegenscheid, K; Heinz, A; Le Hellard, S; Hernandez, DG; Heslenfeld, DJ; Ho, BC; Hoekstra, PJ; Hoffmann, W; Hofman, A; Holsboer, F; Homuth, G; Hosten, N; Hottenga, JJ; Huentelman, M; Hulshoff Pol, HE; Ikeda, M; Jack, CR; Jenkinson, M; Johnson, R; Jönsson, EG; Jukema, JW; Kahn, RS; Kanai, R; Kloszewska, I; Knopman, DS; Kochunov, P; Kwok, JB; Lawrie, SM; Lemaître, H; Liu, X; Longo, DL; Lopez, OL; Lovestone, S; Martinez, O; Martinot, JL; Mattay, VS; McDonald, C; McIntosh, AM; McMahon, FJ; McMahon, KL; Mecocci, P; Melle, I; Meyer-Lindenberg, A; Mohnke, S; Montgomery, GW; Morris, DW; Mosley, TH; Mühleisen, TW; Müller-Myhsok, B; Nalls, MA; Nauck, M; Nichols, TE; Niessen, WJ; Nöthen, MM; Nyberg, L; Ohi, K; Olvera, RL; Ophoff, RA; Pandolfo, M; Paus, T; Pausova, Z; Penninx, BWJH; Pike, GB; Potkin, SG; Psaty, BM; Reppermund, S; Rietschel, M; Roffman, JL; Romanczuk-Seiferth, N; Rotter, JI; Ryten, M; Sacco, RL; Sachdev, PS; Saykin, AJ; ....
Novel genetic loci associated with hippocampal volume.
Nat Commun. 2017; 8(6):13624-13624
Doi: 10.1038/ncomms13624
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hofer Edith
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Pirpamer Lukas
- Ropele Stefan
- Schmidt Helena
- Schmidt Reinhold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Alzheimer Disease - genetics
- Alzheimer Disease - physiopathology
- Child -
- Cohort Studies -
- Dipeptidyl Peptidase 4 - genetics
- Female -
- Genetic Loci -
- Genetic Predisposition to Disease -
- Genome-Wide Association Study -
- Glycoproteins - genetics
- Hippocampus - growth & development
- Humans -
- Male -
- Methionine Sulfoxide Reductases - genetics
- Microtubule-Associated Proteins - genetics
- Middle Aged -
- Nerve Tissue Proteins - genetics
- Organ Size -
- Protein-Serine-Threonine Kinases - genetics
- Young Adult -