Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
González-Vela, MDC; Curiel-Olmo, S; Derdak, S; Beltran, S; Santibañez, M; Martínez, N; Castillo-Trujillo, A; Gut, M; Sánchez-Pacheco, R; Almaraz, C; Cereceda, L; Llombart, B; Agraz-Doblas, A; Revert-Arce, J; López Guerrero, JA; Mollejo, M; Marrón, PI; Ortiz-Romero, P; Fernandez-Cuesta, L; Varela, I; Gut, I; Cerroni, L; Piris, MÁ; Vaqué, JP.
Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.
J Invest Dermatol. 2017; 137(1):197-206
Doi: 10.1016/j.jid.2016.08.015
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Cerroni Lorenzo
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis is not completely understood, despite the role that Merkel cell polyomavirus can play in 55-90% of cases. To study potential mechanisms driving this disease in clinically characterized cases, we searched for somatic mutations using whole-exome sequencing, and extrapolated our findings to study functional biomarkers reporting on the activity of the mutated pathways. Confirming previous results, Merkel cell polyomavirus-negative tumors had higher mutational loads with UV signatures and more frequent mutations in TP53 and RB compared with their Merkel cell polyomavirus-positive counterparts. Despite important genetic differences, the two Merkel cell carcinoma etiologies both exhibited nuclear accumulation of oncogenic transcription factors such as NFAT or nuclear factor of activated T cells (NFAT), P-CREB, and P-STAT3, indicating commonly deregulated pathogenic mechanisms with the potential to serve as targets for therapy. A multivariable analysis identified phosphorylated CRE-binding protein as an independent survival factor with respect to clinical variables and Merkel cell polyomavirus status in our cohort of Merkel cell carcinoma patients. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - genetics
- Biopsy, Needle -
- Carcinogenesis - genetics
- Carcinoma, Merkel Cell - genetics
- Carcinoma, Merkel Cell - mortality
- Carcinoma, Merkel Cell - pathology
- Carcinoma, Merkel Cell - virology
- Cohort Studies -
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Immunohistochemistry -
- Male -
- Merkel cell polyomavirus - genetics
- Merkel cell polyomavirus - isolation & purification
- Multivariate Analysis -
- Mutation -
- Oncogenes - genetics
- Prognosis -
- Risk Assessment -
- Signal Transduction - genetics
- Skin Neoplasms - genetics
- Skin Neoplasms - mortality
- Skin Neoplasms - pathology
- Skin Neoplasms - virology
- Survival Analysis -
- Tumor Suppressor Protein p53 - genetics
- Tumor Suppressor Protein p53 - metabolism
- Tumor Virus Infections - mortality
- Tumor Virus Infections - pathology
- Ultraviolet Rays - adverse effects