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SHR Neuro Cancer Cardio Lipid Metab Microb

Ulz, P; Gerger, A; Belic, J; Heitzer, E.
Potentials, challenges and limitations of a molecular characterization of circulating tumor DNA for the management of cancer patients
LABORATORIUMSMEDIZIN. 2016; 40(5): 323-334. Doi: 10.1515/labmed-2016-0049 [OPEN ACCESS]
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Leading authors Med Uni Graz: Heitzer Ellen; Ulz Peter
Co-authors Med Uni Graz: Belic Jelena; Gerger Armin
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Abstract:: A liquid profiling, i.e. the analysis of cell-free circulating tumor DNA (ctDNA), enables a continuous non-invasive monitoring of tumor-specific changes during the entire course of the disease with respect to early detection, identification of minimal residual disease, assessment of treatment response and monitoring tumor evolution. Technological improvements, advances in understanding the nature of ctDNA, the implementation of ctDNA analyses in clinical trials as well as efforts for the establishment of benchmarks, will bring an actual widespread clinic use within reach in the near future. However, despite this progress there are still hurdles that have to be overcome, which are discussed in this review. Moreover, present knowledge and new findings about the biology of ctDNA as well as selected potential clinical applications for metastatic cancer patients are pointed out.
Find related publications in this database (Keywords): assessment of treatment response; cell-free circulating DNA; ctDNA; identification of actionable targets; monitoring tumor evolution; predictive and prognostic biomarker