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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Markus, MR; Stritzke, J; Baumeister, SE; Siewert, U; Baulmann, J; Hannemann, A; Schipf, S; Meisinger, C; Dörr, M; Felix, SB; Keil, U; Völzke, H; Hense, HW; Schunkert, H; MONICA/KORA Augsburg Cohort Study.
Effects of smoking on arterial distensibility, central aortic pressures and left ventricular mass.
Int J Cardiol. 2013; 168(3):2593-2601
Doi: 10.1016/j.ijcard.2013.03.045
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Baulmann Johannes
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- Abstract:
- The effects of smoking on central aortic pressures and the age-related increase in left ventricular mass (LVM) are largely unknown. We studied the relationship between smoking, arterial distensibility, central aortic pressures and left ventricular mass in two population-based studies. Data was obtained from two German population-based studies (KORA and SHIP, participants' ages 25-84 years). We identified 114 normotensive current smokers and 185 normotensive all-time non-smokers in KORA as well as 400 and 588 such individuals in SHIP. Echocardiographic LVM was obtained at baseline (T0) and follow-up after ten years (T1) in KORA and at follow-up (T1) in SHIP. Additionally, pulse-wave analysis-based central aortic pressure and augmentation index (AIx) were measured at T1 in KORA. Cross-sectional analysis, using KORA T0 and SHIP T1, revealed in both studies a higher covariate-adjusted LVM and left ventricular mass index (LVMI) in smokers as compared with non-smokers. Moreover, in the KORA T1 examination, the smokers demonstrated a more pronounced increase, relative to baseline, of LVM (+13.5%) and LVMI (+13.4%) compared to non-smokers (+8.59% and +8.65%; p=0.036 and 0.042, respectively). Additionally, at KORA T1 smokers had a higher central systolic blood pressure and higher AIx than non-smokers (p=0.012 and p=0.001, respectively). The difference in central aortic pressure due to enhanced and more prolonged wave reflection may explain our finding of a further pronounced increase in left ventricular wall thickness and mass over time in smokers. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Arterial Pressure -
- Arteries - physiopathology
- Female -
- Heart Ventricles - pathology
- Humans -
- Male -
- Organ Size -
- Prospective Studies -
- Smoking - physiopathology
- Find related publications in this database (Keywords)
- Arterial stiffness
- Central aortic pressures
- Echocardiography Left ventricular hypertrophy
- Population-based study
- Smoking