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Friedrich, K; Smit, M; Wannhoff, A; Rupp, C; Scholl, SG; Antoni, C; Dollinger, M; Neumann-Haefelin, C; Stremmel, W; Weiss, KH; Schemmer, P; Gotthardt, DN.
Coffee consumption protects against progression in liver cirrhosis and increases long-term survival after liver transplantation.
J Gastroenterol Hepatol. 2016; 31(8):1470-1475 Doi: 10.1111/jgh.13319
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Co-authors Med Uni Graz: Schemmer Peter
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Abstract:: Therapeutic options to treat progression of end-stage liver disease (ESLD) or improve long-term survival after liver transplantation remain scarce. We investigated the impact of coffee consumption under these conditions. We recorded coffee consumption habits of 379 patients with ESLD awaiting liver transplantation and 260 patients after liver transplantation. Survival was analyzed based on coffee intake. One hundred ninety-five patients with ESLD consumed coffee on a daily basis, while 184 patients did not. Actuarial survival was impaired (P = 0.041) in non-coffee drinkers (40.4 ± 4.3 months, 95% confidence interval [CI]: 32.0-48.9) compared with coffee drinkers (54.9 ± 5.5 months, 95% CI: 44.0-65.7). In subgroup analysis, the survival of patients with alcoholic liver disease (ALD; P = 0.020) and primary sclerosing cholangitis (PSC; P = 0.017) was increased with coffee intake while unaffected in patients with chronic viral hepatitis (P = 0.517) or other liver disease entities (P = 0.652). Multivariate analysis showed that coffee consumption of PSC and ALD patients retained as an independent risk factor (odds ratio [OR]: 1.94; 95% CI: 1.15-3.28; P = 0.013) along with MELD score (OR: 1.13; 95% CI: 1.09-1.17; P = 0.000). Following liver transplantation, long-term survival was longer in coffee drinkers (coffee: 61.8 ± 2.0 months, 95% CI: 57.9-65.8) than non-drinkers (52.3 ± 3.5 months, 95% CI: 45.4-59.3; P = 0.001). Coffee consumption delayed disease progression in ALD and PSC patients with ESLD and increased long-term survival after liver transplantation. We conclude that regular coffee intake might be recommended for these patients. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Cholangitis, Sclerosing - complications; Coffee -; Disease Progression -; End Stage Liver Disease - diagnosis; End Stage Liver Disease - etiology; End Stage Liver Disease - mortality; End Stage Liver Disease - pathology; End Stage Liver Disease - surgery; Female -; Humans -; Kaplan-Meier Estimate -; Liver Cirrhosis - diagnosis; Liver Cirrhosis - mortality; Liver Cirrhosis - pathology; Liver Cirrhosis - surgery; Liver Diseases, Alcoholic - complications; Liver Transplantation - adverse effects; Liver Transplantation - mortality; Male -; Middle Aged -; Multivariate Analysis -; Odds Ratio -; Proportional Hazards Models -; Protective Factors -; Retrospective Studies -; Risk Factors -; Survivors -; Time Factors -; Treatment Outcome -; Waiting Lists - mortality
Find related publications in this database (Keywords): actuarial survival free of liver transplantation; coffee consumption; graft failure; liver transplantation; transplantation list