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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Süsal, C; Döhler, B; Ruhenstroth, A; Morath, C; Slavcev, A; Fehr, T; Wagner, E; Krüger, B; Rees, M; Balen, S; Živčić-Ćosić, S; Norman, DJ; Kuypers, D; Emonds, MP; Pisarski, P; Bösmüller, C; Weimer, R; Mytilineos, J; Scherer, S; Tran, TH; Gombos, P; Schemmer, P; Zeier, M; Opelz, G; Collaborative Transplant Study Report.
Donor-specific antibodies require preactivated immune system to harm renal transplant.
EBioMedicine. 2016; 9(1):366-371
Doi: 10.1016/j.ebiom.2016.06.006
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect. The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients. A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or without DSA (83.1±3.9% and 84.3±2.8%, P=0.81). A strikingly lower 3-year graft survival rate of 62.1±6.4% was observed in patients who were both sCD30 and DSA positive (HR 2.92, P<0.001). Even in the presence of strong DSA with ≥5000 MFI, the 3-year graft survival rate was high if the recipients were sCD30 negative. Pretransplant DSA have a significantly deleterious impact on graft survival only in the presence of high pretransplant levels of the activation marker sCD30. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD30 - blood
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Graft Survival -
- HLA Antigens - blood
- HLA Antigens - immunology
- Humans -
- Immune System - metabolism
- Kidney Failure, Chronic - therapy
- Kidney Transplantation -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Retrospective Studies -
- T-Lymphocytes - cytology
- T-Lymphocytes - metabolism
- Tissue Donors -
- Find related publications in this database (Keywords)
- Single antigen bead
- HLA antibodies
- Donor-specific antibodies
- sCD30
- Kidney transplantation
- Graft outcome