Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Czink, E; Heining, C; Weber, TF; Lasitschka, F; Schemmer, P; Schirmacher, P; Weiss, KH; Glimm, H; Brors, B; Weichert, W; Jäger, D; Fröhling, S; Springfeld, C.
[Durable remission under dual HER2 blockade with Trastuzumab and Pertuzumab in a patient with metastatic gallbladder cancer].
Z Gastroenterol. 2016; 54(5):426-430
Doi: 10.1055/s-0042-103498
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Gallbladder cancer represents a rare but dismal disease. The only curative option is complete surgical resection, though patients often develop recurrent disease. In patients with advanced biliary tract cancer, the combination of cisplatin and gemcitabine showed a benefit in overall survival compared to gemcitabine alone. However, there is no standardized second-line regimen after treatment failure. We report on a young patient with early recurrence of a gallbladder cancer with cutaneous and peritoneal metastases. Upon identification of an ERBB2 gene amplification within the NCT MASTER (Molecularly Aided Stratification for Tumor Eradication Research) exome sequencing program with resulting overexpression of HER2 in the tumors cells, the patient received a targeted therapy with the HER2 antibodies pertuzumab and trastuzumab in combination with nab-paclitaxel, which led to a durable remission for more than one year. This case report underlines the potential of molecularly aided personalized targeted therapy for patients with biliary tract cancer and the need for respective clinical trials. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies, Monoclonal, Humanized - administration & dosage
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage
- Carcinoma - drug therapy
- Carcinoma - pathology
- Carcinoma - secondary
- Female -
- Gallbladder Neoplasms - drug therapy
- Gallbladder Neoplasms - pathology
- Humans -
- Molecular Targeted Therapy - methods
- Neoplasm Recurrence, Local - drug therapy
- Neoplasm Recurrence, Local - pathology
- Receptor, ErbB-2 - antagonists & inhibitors
- Remission Induction - methods
- Trastuzumab - administration & dosage
- Treatment Outcome -
- Find related publications in this database (Keywords)
- biliary tract cancer
- gall bladder cancer
- HER2
- Pertuzumab
- Trastuzumab