Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Dimai, HP; Porta, S; Wirnsberger, G; Dobnig, H; Leb, G; Truschnigwilders, M.
Magnesium Supplementation for 30 Days Leads to Correlative Changes in Circulating Ionized Magnesium and Parathormone (Ipth)
MAGNESIUM, BULL 1994 16: 113-118.
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Führende Autor*innen der Med Uni Graz: Dimai Hans Peter
Co-Autor*innen der Med Uni Graz: Dobnig Harald; Porta Sepp; Truschnig-Wilders Martini; Wirnsberger Gerhard
Altmetrics:
Abstract:: 9 healthy probands were supplemented with 316 mmol magnesium (Asta Medica) per day for 30 days. Blood samples were collected at day 0, 5, 10, 20 and 30. iPTH, total and ionized magnesium were measured and bound magnesium was calculated as the difference from total to ionized magnesium. It turned out, that total magnesium levels did not change throughout the whole time of the experiment, while ionized magnesium decreased during the first 10 days and bound magnesium tended to increase. Ionized magnesium and not calcium was positively correlated with iPTH throughout the experiment. There were also correlations within the groups at the different sampling times. On day 0 calcium (barely) and ionized magnesium (nicely) correlated with iPTH levels. Both the correlations vanished after the begin of magnesium supplementation, the one with calcium for good, but the correlation with ionized magnesium and iPTH became significant again at day 20 and 30, when the absolute levels of ionized magnesium did increase again. If this correlative behaviour of iPTH and ionized magnesium above a certain minimal level of ionized magnesium proves to be true in general, then the paradox decrease of ionized magnesium in the first stages of magnesium supplementation makes sense. By keeping the levels of iPTH down, it ensures that supplemented magnesium does enter the bone and is not liberated along with calcium by possibly increased iPTH levels, triggered by high circulating magnesium concentrations.