Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Khan, A; Dellago, H; Terlecki-Zaniewicz, L; Karbiener, M; Weilner, S; Hildner, F; Steininger, V; Gabriel, C; Mück, C; Jansen-Dürr, P; Hacobian, A; Scheideler, M; Grillari-Voglauer, R; Schosserer, M; Grillari, J.
SNEVhPrp19/hPso4 Regulates Adipogenesis of Human Adipose Stromal Cells.
Stem Cell Reports. 2017; 8(1):21-29
Doi: 10.1016/j.stemcr.2016.12.001
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- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
- Karbiener Michael
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- Abstract:
- Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipogenesis - genetics
- Adipose Tissue - cytology
- Animals -
- Caenorhabditis elegans -
- Cell Differentiation - genetics
- DNA Damage -
- DNA Repair Enzymes - genetics
- DNA Repair Enzymes - metabolism
- Gene Expression -
- Gene Knockdown Techniques -
- Humans -
- Insulin - metabolism
- Nuclear Proteins - genetics
- Nuclear Proteins - metabolism
- Oxidative Stress -
- PPAR gamma - metabolism
- RNA Splicing Factors - genetics
- RNA Splicing Factors - metabolism
- Stromal Cells - cytology
- Stromal Cells - metabolism