Medizinische Universität Graz - Research portal
Selected Publication:
Porta, S; Gebru, G; Slawitsch, P; Liebmann, P; Epple, A; Zirm, B.
Magnesium Pretreatment Alters the Ratio of Free to Conjugated Plasma Dopamine After Exhaustive Stress
MAGNESIUM, BULL. 1994; 16: 77-80.
Web of Science
- Leading authors Med Uni Graz
- Porta Sepp
- Co-authors Med Uni Graz
- Liebmann-Holzmann Peter
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- Abstract:
- 18 officer trainees of the Theresianische Militarakademie were subjected to three different stresses: 1. 5 minutes of Harvard step test repeated twice within the hour, 2. their very first parachute jump and 3. a long exhaustive march in combat formation with a time interval of several months between each of them. Previous to those stresses the probands were subdivided into two groups. The test group was treated with 15 mM/day Magnesiumaspartatehydrochloride (Verla Pharm, Tutzing, BRD), for 10 days, the control group with placebo in a double blind manner. After the experiment 2. and 3.. an additional Harvard step test had to be absolved to be able to detect eventual cumulation of the conjugated catecholamine. Blood has been sampled from the cannulated antecubital vein before and after the stresses. In this paper we present the values of free and conjugated dopamine in the plasma of the probands. It turned out, that magnesium pretreatment does influence circulating dopamine levels towards a lesser concentration of free and a higher concentration of the conjugated fraction than in placebo treated stressed persons. But this became only significant after a long strenuous exercise, which points to a possible participation of muscle tissue in this process.