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Gambichler, T; Majert, J; Pljakic, A; Rooms, I; Wolf, P.
Determination of the minimal erythema dose for ultraviolet A1 radiation.
Br J Dermatol. 2017; 177(1):238-244 Doi: 10.1111/bjd.15245
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Co-authors Med Uni Graz: Wolf Peter
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Abstract:: There is limited knowledge of the potential of ultraviolet A1 (UVA1) radiation to induce erythema. To investigate the minimal erythema dose (MED) for UVA1 in a German and Austrian population and to determine UVA1 dose-response curves for erythema and pigmentation. We determined the UVA1-MED in 59 participants using a geometric increase in the dose. Visual readings of erythema and pigmentation were performed at 10 min, 2 h and 24 h after the UVA1 irradiation. Colorimetric measurements were taken to determine erythema (a* value) and pigmentation (L* value) objectively. More than 30% (18 of 59) of the participants had a high-dose UVA1-MED (> 70-130 J cm^-2 ); 56% (33) had no detectable UVA1-MED after 24 h and eight (14%) had a medium-dose UVA1-MED (20-70 J cm^-2 ). We observed a stepwise decrease of the a* value measured at the UVA1-MED skin site from 10 min to 2 h and 24 h (P < 0·001). In contrast, there was a stepwise increase of the L* value measured at the UVA1-MED skin site from 10 min to 2 h and 24 h (P < 0·001). Most participants had no measurable UVA1-MED even after commencing high doses such as 130 J cm^-2 . Only a minority of participants (14%) may develop UVA1-induced erythema in the low- and medium-dose region. Hence, it appears to be safe to start UVA1 phototherapy with 20 J cm^-2 of UVA1 and continue with subsequent daily dose increments of 10 J cm^-2 , up to the desired maximum dose. © 2016 British Association of Dermatologists.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Dose-Response Relationship, Radiation -; Erythema - etiology; Female -; Humans -; Male -; Middle Aged -; Pigmentation Disorders - etiology; Prospective Studies -; Radiation Dosage -; Skin Diseases - therapy; Ultraviolet Rays - adverse effects; Ultraviolet Therapy - adverse effects; Young Adult -