Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zidar, N; Langner, C; Odar, K; Hošnjak, L; Kamarádová, K; Daum, O; Pollheimer, MJ; Košorok, P; Poljak, M.
Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguished from giant condyloma (Buschke-Löwenstein tumour).
Histopathology. 2017; 70(6):938-945
Doi: 10.1111/his.13158
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Langner Cord
- Pollheimer Marion
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- Abstract:
- Verrucous carcinoma (VC) is a variant of well-differentiated squamous cell carcinoma and in the anal region is regarded as synonymous with giant condyloma (Buschke-Löwenstein tumour) (BLT). Aetiology, diagnostic criteria and clinical behaviour of both lesions are controversial. Recent studies suggest that VC at other sites is not associated with human papillomaviruses (HPV). We hypothesized that anal VC is also not related to HPV, while BLT is a HPV-induced lesion. Ten cases of VC and four cases of BLT were included. Several techniques were used for HPV detection: in-situ hybridization for HPV6, 11, 16 and 18, six different polymerase chain reaction (PCR) protocols for detection of at least 89 HPV types from alpha-, beta-, gamma- and mu-PV genera and in-situ hybridization for high-risk HPV E6/E7 mRNA; p16 immunohistochemistry and morphometric analysis were also performed. Alpha-, gamma- and mu-PVs were not found in any case of VC, while HPV6 was detected in all cases of BLT. p16 overexpression was not present in any of the lesions. Among microscopic features, only the absence of koilocytosis and enlarged spinous cells seem to be useful to distinguish VC from BLT. Our results suggest that anal VC, similarly to VC at other sites, is not associated with HPV infection, and must be distinguished from BLT, which is associated with low-risk HPV. Only with well-set diagnostic criteria will it be possible to ascertain clinical behaviour and optimal treatment for both lesions. © 2016 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anus Neoplasms - pathology
- Anus Neoplasms - virology
- Buschke-Lowenstein Tumor - pathology
- Buschke-Lowenstein Tumor - virology
- Carcinoma, Verrucous - pathology
- Carcinoma, Verrucous - virology
- Female -
- Humans -
- Immunohistochemistry -
- In Situ Hybridization -
- Male -
- Middle Aged -
- Papillomavirus Infections - complications
- Papillomavirus Infections - epidemiology
- Polymerase Chain Reaction -
- Find related publications in this database (Keywords)
- anal giant condyloma
- anal verrucous carcinoma
- Buschke-Lowenstein tumour
- human papillomaviruses