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Gewählte Publikation:

Weiss, U; Alkharrat, H; Nibbio, B; Porta, S; Epple, A.
Magnesium and Nicotinergic Effects on Catecholamine Release from Chromaffin Cells
MAGNESIUM, BULL 1996 18: 63-65.
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Co-Autor*innen der Med Uni Graz

Porta Sepp

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Abstract:

In an in vitro model, the perifused posterior cardinal vein of the eel, norepinephrine (NE) and epinephrine (E) are released from the equivalent of the adrenal medulla, while dopamine (DA) probably derives from vascular tissue. A low concentration of nicotine (250 ng/ml) stimulates the release of NE, while a higher concentration (1 mu g/ml) stimulates the release of all three catecholamines. Magnesium (5.6 mM) reduces NE and E release without a significant effect on DA release. Nicotine overrides the magnesium effect. The differential catecholamine responses to magnesium may contribute to the anti-stress effect of magnesium seen in vivo.

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