Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Regauer, S; Eberz, B; Reich, O.
Human Papillomavirus-Induced Squamous Intraepithelial Lesions in Vulvar Lichen Planus.
J Low Genit Tract Dis. 2016; 20(4):360-364
Doi: 10.1097/LGT.0000000000000248
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Regauer Sigrid
- Co-Autor*innen der Med Uni Graz
- Reich Olaf
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Approximately 50% of vulvar cancers arise after transforming infections with human papilloma virus (HPV) via the precursor squamous intraepithelial lesion (SIL). Lichen planus (LP)-associated vulvar cancers are typically HPV negative and arise via the precursor differentiated vulvar intraepithelial neoplasia (d-VIN). An index case of vulvar high-grade squamous intraepithelial lesion (H-SIL) in an LP patient prompted this 12-year retrospective analysis about frequency of HPV-induced SIL in 785 biopsies of 584 patients with vulvar LP. All SIL were analyzed for p53 and p16 overexpression and for presence of DNA of 32 HPV subtypes. Nine (1.6%) of 584 women with papular (3) and mucosal "erosive" LP (6) presented with H-SIL (7) and low-grade SIL (2). All SILs harbored HPV16-DNA and showed p16-overexpression. Concomitant immune suppression included T-suppressor lymphocyte deficit (1), systemic (1), and topical (2) cortisone therapy. H-SILs regressed spontaneously (1) or after imiquimod therapy (3). Three women with erosive LP discontinued imiquimod because of side effects and had laser destruction (1), skinning vulvectomy (1), and surgery (1) for definitive treatment. Two women have recurrent vulvar SILs, and 1 woman progressed to invasive SCC. In the same patient population, 16 of 584 women had a d-VIN, and 9 of 16 with progression to SCC. H-SILs in vulvar LP are rare and may occur in the setting of risk factors. If clinical suspicion arises, biopsy and histological examination assist in correct etiologic classification of a precancerous lesion and subsequent therapy decisions. The minimal risk for H-SIL development in vulvar LP patients should not preclude therapy of LP.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biopsy -
- Cyclin-Dependent Kinase Inhibitor p16 - analysis
- DNA, Viral - analysis
- Female -
- Humans -
- Lichen Planus - complications
- Lichen Planus - pathology
- Middle Aged -
- Papillomavirus Infections - complications
- Papillomavirus Infections - pathology
- Retrospective Studies -
- Squamous Intraepithelial Lesions of the Cervix - epidemiology
- Squamous Intraepithelial Lesions of the Cervix - pathology
- Tumor Suppressor Protein p53 - analysis
- Vulvar Diseases - epidemiology
- Vulvar Diseases - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- HPV-negative vulvar carcinoma
- squamous intraepithelial lesion
- vulvar precursors
- vulvar dermatosis
- vulvar intraepithelial neoplasia
- vulvar squamous cell carcinoma
- differentiated vulvar intraepithelial neoplasia