Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zanichelli, A; Maurer, M; Aberer, W; Caballero, T; Longhurst, HJ; Bouillet, L; Fabien, V; Andresen, I; IOS Study Group.
Long-term safety of icatibant treatment of patients with angioedema in real-world clinical practice.
Allergy. 2017; 72(6):994-998
Doi: 10.1111/all.13103
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- The Icatibant Outcome Survey (IOS) is an observational study monitoring safety and effectiveness of icatibant in the real-world setting. We analyzed safety data from 3025 icatibant-treated attacks in 557 patients (enrolled between July 2009 and February 2015). Icatibant was generally well tolerated. Excluding off-label use and pregnancy, 438 patients (78.6%) did not report adverse events (AEs). The remaining 119 (21.4%) patients reported 341 AEs, primarily gastrointestinal disorders (19.6%). Of these, 43 AEs in 17 patients (3.1%) were related to icatibant. Serious AEs (SAEs) occurred infrequently. A total of 143 SAEs occurred in 59 (10.6%) patients; only three events (drug inefficacy, gastritis, and reflux esophagitis) in two patients were considered related to icatibant. Notably, no SAEs related to icatibant occurred in patients with cardiovascular disease, nor in those using icatibant at a frequency above label guidelines. Additionally, no major differences were noted in AEs occurring in on-label vs off-label icatibant users. © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Angioedema - drug therapy
- Anti-Inflammatory Agents, Non-Steroidal -
- Bradykinin - adverse effects
- Bradykinin - analogs & derivatives
- Bradykinin - therapeutic use
- Cardiovascular Diseases -
- Female -
- Gastrointestinal Diseases - chemically induced
- Humans -
- Male -
- Off-Label Use - standards
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- angioedema
- icatibant
- real-world
- safety