Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Porta, S; Thompson, E; Otton, R; Bacher, H; Heidinger, D; Smolle, KH; Supanz, S; Mitterhammer, H.
Magnesium - Electrolytes and Blood-Gases During Acute Alcohol Uptake at Wine Festivals
MAGNESIUM, BULL 1999 21: 14-20.
Web of Science
- Führende Autor*innen der Med Uni Graz
- Porta Sepp
- Co-Autor*innen der Med Uni Graz
- Bacher Heinz
- Mitterhammer Heike
- Smolle Karl-Heinz
- Supanz Sabine
- Altmetrics:
- Abstract:
- The influence of chronic alcoholism upon magnesium state has already been shown by Siegenthaler (1987) or McCollister as early as 1963. Much less is known about magnesium reaction to acute ethanol intoxication in man. since determination of magnesium status during in vivo investigations in man must confine itself to (ionized) serum magnesium values, their correct interpretation is important. Interpretation however strongly depends upon the fact, whether dietetic alterations or stress are causing the magnesium changes. In a field experiment we therefore did not only measure electrolyte changes correlative with changes in blood ethanol content (BEC), but also changes in blood gases, pH and lactate for differential diagnosis of serum magnesium levels in 62 female and male probands at a ''Klocher Traminer'' wine festival. Regardless of their actual BEC, the probands were asked to return 30 minutes after their first blood sampling and were encouraged to keep on consuming alcohol or not, just to their liking. Most important results: 1. Ethanol uptake up to 0.5 promille leads to a clear fall in blood pH along with a slight fall in pO(2), which points i.a. towards an increased oxygen release into tissues. 2. With increasing ethanol consumption, pH and BE values increase by way of backregulation, which would explain the existence of pseudonormal pH or BE values at higher degrees of intoxication. 3. Electrolyte loss in the higher promille range hits Mg selectively hard, it increases along the ratio Na: Ca: Mg geometrically 1:2:4.