Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Klein, M; Rosen, A; Lahousen, M; Graf, A; Vavra, N; Beck, A; Rainer, A.
Lymphogenous metastasis in the primary carcinoma of the fallopian tube.
Gynecol Oncol. 1994; 55(3 Pt 1):336-338
Doi: 10.1006/gyno.1994.1302
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- Co-Autor*innen der Med Uni Graz
- Lahousen Manfred
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- Abstract:
- The bad prognosis of primary Fallopian tube carcinoma (FTC) is mostly ascribed to early lymphogenous metastasis. Yet, there is a lack of information on the tumor size at which lymph node metastasis must be expected to occur. Our study was therefore designed to correlate the anatomopathologic substratum and the histologic results with the lymph node status. Data were obtained from 21 women who received primary surgery, during which additional total pelvic and para-aortic lymphadenectomy was performed as well. The "surgical" staging was compared to the final clinical staging after histologic inspection of the lymph nodes according to the FIGO classification. Lymph node metastases never occurred as long as the tumor was confined to the tube (stage I). Lymphogenous dissemination set in only after further, local expansion of the tumor, involving the ovaries, the peritoneum, or the uterus (surgical stage II); 3 of the 7 patients of surgical stage II had to be reclassified to stage III because of manifest lymph node metastases. After the onset of intra-abdominal or general metastasis (stage IV), lymph node metastases occurred significantly more often (P = 0.048). Due to the specific lymphatic drainage, lymphogenous metastasis must be expected to spread as far as to the para-aortic region even in the early stages. Highly differentiated tumors (G I) do not disseminate into the lymphatic system, not even in advanced stages, whereas anaplastic tumors (G II and III) metastasize relatively early. As soon as metastasis has occurred, prognosis of life diminishes markedly, but not significantly (49 versus 24 months, P = 0.19). Correct FTC-staging is obtained only on the basis of pelvic and para-aortic lymphadenectomy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aorta, Abdominal -
- Fallopian Tube Neoplasms - mortality
- Female - mortality
- Humans - mortality
- Lymph Nodes - pathology
- Lymphatic Metastasis - pathology
- Middle Aged - pathology
- Neoplasm Staging - pathology
- Pelvis - pathology
- Prognosis - pathology
- Survival Rate - pathology