Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Friedrich, K; Baumann, C; Brune, M; Wannhoff, A; Rupp, C; Scholl, SG; Antoni, C; Dollinger, M; Neumann-Haefelin, C; Weiss, KH; Stremmel, W; Schemmer, P; Gotthardt, DN.
Association of serum zinc levels with liver function and survival in patients awaiting liver transplantation.
Langenbecks Arch Surg. 2015; 400(7):805-811
Doi: 10.1007/s00423-015-1334-7
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Zinc is an important trace element with catalytic and defensive functions. We assessed the impact of zinc deficiency in patients with end-stage liver disease awaiting liver transplantation. Serum zinc levels were measured at the time of evaluation for liver transplantation (n = 368). Patients were dichotomized in two groups based on low and normal zinc serum levels. Serum zinc levels are tightly associated with liver function as patients with low zinc levels (n = 226) had a higher Model for End-Stage Liver Disease (MELD) score (15.0 [5.0-40.0]) than patients with normal zinc (n = 142) levels (9.0 [6.0-34.0]; p < 0.00). Multivariate analysis demonstrated that serum zinc levels function as an independent predictor of hepatic decompensation (hydropic decompensation: odds ratio [OR] 0.82; 95% confidence interval [CI] 0.70-0.96; p = 0.015; hepatic encephalopathy: OR 0.80; 95% CI 0.71-0.90; p = 0.000; spontaneous bacterial peritonitis: OR 0.85; 95% CI 0.72-1.00; p = 0.047; hepatorenal syndrome: OR 0.83; 95% CI 0.72-0.95; p = 0.011). Actuarial survival free of liver transplantation was reduced for low-zinc patients (26.7 ± 4.0 months; 95% CI 18.8-34.6) compared to patients with normal zinc levels (30.9 ± 3.0 months; 95% CI 24.9-36.9; p = 0.008). Reduction of zinc levels for patients on the transplantation list resulted in a 28.3-fold increased risk of death/liver transplantation (95% CI 3.2-244.8, p < 0.001). Serum zinc levels are associated with reduced survival in end-stage liver disease patients. Whether or not zinc supplementation might be beneficial for patients on a liver transplantation list requires further study.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Cause of Death -
- Cohort Studies -
- Confidence Intervals -
- Female -
- Follow-Up Studies -
- Graft Rejection -
- Graft Survival -
- Humans -
- Kaplan-Meier Estimate -
- Liver Failure - blood
- Liver Failure - mortality
- Liver Failure - surgery
- Liver Function Tests -
- Liver Transplantation - adverse effects
- Liver Transplantation - methods
- Liver Transplantation - mortality
- Male -
- Middle Aged -
- Multivariate Analysis -
- Preoperative Care - methods
- Proportional Hazards Models -
- Retrospective Studies -
- Risk Assessment -
- Statistics, Nonparametric -
- Survival Rate -
- Treatment Outcome -
- Waiting Lists -
- Young Adult -
- Zinc - blood
- Find related publications in this database (Keywords)
- Serumzinc levels
- Liver transplantation
- End-stage liver disease
- Actuarial survival free of liver transplantation