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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mehrabi, A; Golriz, M; Adili-Aghdam, F; Hafezi, M; Ashrafi, M; Morath, C; Zeier, M; Hackert, T; Schemmer, P.
Expanding the indications of pancreas transplantation alone.
Pancreas. 2014; 43(8):1190-1193
Doi: 10.1097/MPA.0000000000000181
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Total pancreatectomy (TP) is associated with postoperative endocrine and exocrine insufficiency. Especially, insulin therapy reduces quality of life and may lead to long-term complications. We review the literature with regard to the potential option of pancreas transplantation alone (PTA) after TP in patients with chronic pancreatitis or benign tumors. A MEDLINE search (1958-2013) using the terminologies pancreas transplantation, pancreas transplantation alone, total pancreatectomy, morbidity, mortality, insulin therapy, and quality of life was performed. In addition, the current book and congress publications were reviewed. Total pancreatectomy after benign and borderline tumors as well as chronic pancreatitis is continuously increasing. Despite improvement of exogenous insulin therapy, more than 50% of these patients experience severe glucose control problems, which cause up to 50% long-term mortality. Pancreas transplantation alone can cure both endocrine and exocrine insufficiency and reduce the associated risks. The 3-year graft and patient survival rates after PTA are up to 73% and 100%, respectively. Pancreas transplantation alone after TP in patients with pancreatitis or benign tumors improves the recipient's quality of life and reduces long-term mortality. Considering the amount of available organs and potential candidates, PTA can be a treatment option for patients after TP with chronic pancreatitis or benign tumors.
- Find related publications in this database (using NLM MeSH Indexing)
- Cost-Benefit Analysis -
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - economics
- Diabetes Mellitus, Type 1 - etiology
- Diabetes Mellitus, Type 1 - surgery
- Exocrine Pancreatic Insufficiency - etiology
- Exocrine Pancreatic Insufficiency - surgery
- Global Health -
- Graft Survival -
- Humans -
- Immunosuppressive Agents - adverse effects
- Immunosuppressive Agents - therapeutic use
- Insulin - economics
- Insulin - therapeutic use
- Islets of Langerhans Transplantation - economics
- Pancreas Transplantation - economics
- Pancreas Transplantation - methods
- Pancreas Transplantation - utilization
- Pancreatectomy - adverse effects
- Pancreatic Neoplasms - surgery
- Pancreatitis, Chronic - surgery
- Postoperative Complications - economics
- Postoperative Complications - mortality
- Postoperative Complications - psychology
- Postoperative Complications - surgery
- Quality of Life -
- Tissue and Organ Procurement -
- Treatment Outcome -
- Waiting Lists -
- Find related publications in this database (Keywords)
- TP - total pancreatectomy
- PTA - pancreas transplantation alone
- PT - pancreas transplantation