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Oweira, H; Lahdou, I; Daniel, V; Hofer, S; Mieth, M; Schmidt, J; Schemmer, P; Opelz, G; Mehrabi, A; Sadeghi, M.
Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients.
Hum Immunol. 2016; 77(1): 115-120.
Doi: 10.1016/j.humimm.2015.11.003
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Bacterial infections are the most common complications, and the major cause of mortality after liver transplantation (Tx). Neopterin, a marker of immune activation, is produced in monocyte/macrophages in response to inflammation. The aim of our study was to investigate whether early post-operation serum levels of neopterin were associated with post-transplant bacteremia and mortality in liver transplant recipients. We studied 162 of 262 liver Tx patients between January 2008 and February 2011 of whom pre- and early post-Tx sera samples were available. Pre- and early post-operative risk factors of infection and mortality were evaluated in 45 bacteremic patients and 117 non-bacteremic patients. During one-year follow-up, 28 of 262 patients died because of graft failure, septicemia and other diseases. Post-Tx serum neopterin on day 10 (p<0.001) were significantly higher in bacteriemic patients than in patients without bacteremia. Logistic regression analyses showed that day 10 post-Tx neopterin serum level ⩾40 nmol/l has a predictive value (OR=6.86: p<0.001) for bacteremia and mortality (OR=3.47: p=0.021). Our results suggest that early post-Tx neopterin serum levels are very sensitive predictive markers of one-year post-Tx bacteremia and mortality in liver Tx recipients. Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bacteremia - diagnosis
- Bacteremia - mortality
- Biomarkers - blood
- Female -
- Follow-Up Studies -
- Humans -
- Inflammation - diagnosis
- Inflammation - mortality
- Liver Transplantation - mortality
- Male -
- Middle Aged -
- Neopterin - blood
- Predictive Value of Tests -
- Prognosis -
- Sensitivity and Specificity -
- Survival Analysis -
- Find related publications in this database (Keywords)
- Liver
- Transplantation
- Neopterin
- Outcome