Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cimenti, C; Schlagenhauf, A; Leschnik, B; Fröhlich-Reiterer, E; Jasser-Nitsche, H; Haidl, H; Suppan, E; Weinhandl, G; Leberl, M; Borkenstein, M; Muntean, WE.
Only minor changes in thrombin generation of children and adolescents with type 1 diabetes mellitus - A case-control study.
Thromb Res. 2016; 148(8):45-49
Doi: 10.1016/j.thromres.2016.10.016
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cimenti Christina
- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- Fröhlich-Reiterer Elke
- Haidl Harald
- Jasser-Nitsche Hildegard
- Leschnik Bettina
- Schlagenhauf Axel
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- Abstract:
- Micro- and macrovascular diseases are frequent complications in patients with diabetes. Hypercoagulability may contribute to microvascular alterations. In this study, we investigated whether type 1 diabetes in children is associated with a hypercoagulable state by performing a global function test of coagulation - the thrombin generation assay. 75 patients with type 1 diabetes aged between 2 and 19years were compared to an age-matched healthy control group. Diabetes patients were divided into high-dose and low-dose insulin cohorts with a cut-off at 0.8Ukg-1d-1. Measurements were performed with platelet poor plasma using Calibrated Automated Thrombography and 1 pM or 5 pM tissue factor. Additionally, we quantified prothrombin fragments F1+2, thrombin-antithrombin complex, prothrombin, tissue factor pathway inhibitor, and antithrombin. Patients with type 1 diabetes exhibited a significantly shorter of lag time as well as decreased thrombin peak and endogenous thrombin potential compared to control subjects with 5 pM but not with 1 pM tissue factor. In high-dose insulin patients peak thrombin generation was higher and time to peak shorter than in low-dose patients. Thrombin-antithrombin complex was decreased in patients with type 1 diabetes, whereas prothrombin fragments F1+2 was comparable in both groups. Thrombin generation parameters did not correlate with parameters of metabolic control and the duration of diabetes. Taken together, we found only minor changes of thrombin generation in children and adolescents with type 1 diabetes which - in contrast to type 2 diabetes - do not argue for a hypercoagulable state. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antithrombin III - metabolism
- Blood Coagulation -
- Case-Control Studies -
- Child -
- Child, Preschool -
- Diabetes Mellitus, Type 1 - blood
- Diabetes Mellitus, Type 1 - drug therapy
- Diabetes Mellitus, Type 1 - metabolism
- Female -
- Humans -
- Hypoglycemic Agents - therapeutic use
- Insulin - therapeutic use
- Male -
- Peptide Hydrolases - blood
- Peptide Hydrolases - metabolism
- Thrombin - analysis
- Thrombin - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- Hemostasis - blood coagulation test - diabetes mellitus
- Type 1-child - adolescent