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Doehn, JM; Winkler, A; Kuzmina, Z; Hladik, A; Greinix, H; Knapp, S; Robak, O.
Pentraxin-3 levels in graft-versus-host disease during allogeneic hematopoietic stem cell transplantation.
Exp Hematol. 2016; 44(10):917-923 Doi: 10.1016/j.exphem.2016.07.002
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Greinix Hildegard
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Abstract:: Acute and chronic graft-versus-host-diseases (aGVHD and cGVHD, respectively) are serious complications after hematopoietic stem cell transplantation (HSCT), impairing survival and quality of life. Because the underlying pathomechanism of GVHD is still poorly understood, we investigated the novel inflammatory marker Pentraxin-3 (PTX3) for its potential role in acute and chronic GVHD compared with autologous HSCT and healthy individuals. We collected plasma samples from patients undergoing autologous (n = 12) and allogeneic (n = 28) HSCT and from healthy individuals (n = 15) throughout 7 days before and up to 1 year after HSCT. PTX3 levels in patients with aGVHD were significantly higher (36.4 ± 23.6 ng/mL) than in allogeneic patients without aGVHD (10.4 ± 4.4 ng/mL, p = 0.0001), autologous controls (11.4 ± 6.7 ng/mL, p = 0.001), or healthy individuals (1.9 ± 0.6 ng/mL, p < 0.001). PTX3 levels in patients with cGVHD (13.6 ± 6.3 ng/mL) were significantly lower than in allogeneic patients without cGVHD (25.1 ± 13.8 ng/mL, p = 0.04) and higher than in autologous controls (8.9 ± 7.8 ng/mL, p = 0.07) and healthy individuals (1.9 ± 0.6 ng/mL, p < 0.001). Severity of aGVHD and cGVHD correlated with PTX3 levels. Rising PTX3 levels after HSCT indicated unfavorable outcome. We show that PTX3 levels correlate with the severity of aGVHD, cGVHD, and-with reservations-survival in patients undergoing allogeneic HSCT. Copyright © 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Acute Disease -; Adult -; Biomarkers -; C-Reactive Protein -; Chronic Disease -; Female -; Graft vs Host Disease - blood; Graft vs Host Disease - diagnosis; Graft vs Host Disease - drug therapy; Graft vs Host Disease - etiology; Hematopoietic Stem Cell Transplantation - adverse effects; Humans -; Male -; Middle Aged -; Mortality -; Prognosis -; Prospective Studies -; Serum Amyloid P-Component -; Severity of Illness Index -; Tissue Donors -; Transplantation Conditioning -; Transplantation, Autologous -; Transplantation, Homologous -