Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Turyanskaya, A; Rauwolf, M; Grunewald, TA; Meischel, M; Stanzl-Tschegg, S; Loffler, JF; Wobrauschek, P; Weinberg, AM; Lichtenegger, HC; Streli, C.
mu XRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
MATERIALS. 2016; 9(10): 811
Doi: 10.3390/ma9100811
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- Co-Autor*innen der Med Uni Graz
- Weinberg Annelie-Martina
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- Abstract:
- This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (mu XRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered.
- Find related publications in this database (Keywords)
- elemental imaging
- yttrium
- magnesium
- biodegradable Mg implants
- bone
- mu XRF