Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ferrara, G; Cerroni, L.
Cold-Associated Perniosis of the Thighs ("Equestrian-Type" Chilblain): A Reappraisal Based on a Clinicopathologic and Immunohistochemical Study of 6 Cases.
Am J Dermatopathol. 2016; 38(10):726-731
Doi: 10.1097/DAD.0000000000000477
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Cold-associated perniosis of the thighs ("equestrian cold panniculitis") is an unusual and still enigmatic entity. The authors retrieved 6 cases for a re-evaluation of their clinicopathologic features and for an immunohistochemical assessment with antibodies anti-CD3, anti-CD20, and anti-CD123. All patients were women, aged 17-45 years. One of them had elevated antinuclear antibody titers. Available anamnestic data confirmed the triggering role of prolonged/intermittent exposure to cold (not necessarily for equestrian activities). The lesions affected the thighs, with a preferential, although not exclusive involvement of the upper lateral surface. The histopathological pattern was perivascular, superficial, and deep, extending toward the superficial fat lobules, with lymphocytic vasculitis and mucin deposition; clumps of CD123 cells were found in 4 of 6 cases. Cold-associated perniosis of the thighs cannot be considered as a panniculitis. The histopathological features considerably overlap with perniosis at other sites of the body and with chilblain lupus erythematosus.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - chemistry
- Adipose Tissue - pathology
- Adolescent -
- Adult -
- Antigens, CD20 - analysis
- Biomarkers - analysis
- Blood Vessels - pathology
- CD3 Complex - analysis
- Chilblains - classification
- Chilblains - diagnosis
- Chilblains - etiology
- Chilblains - pathology
- Cold Temperature - adverse effects
- Dermis - blood supply
- Dermis - chemistry
- Dermis - pathology
- Diagnosis, Differential -
- Female -
- Humans -
- Immunohistochemistry -
- Interleukin-3 Receptor alpha Subunit - analysis
- Lupus Erythematosus, Cutaneous - pathology
- Middle Aged -
- Panniculitis - classification
- Panniculitis - diagnosis
- Panniculitis - etiology
- Panniculitis - pathology
- Predictive Value of Tests -
- Terminology as Topic -
- Thigh -
- Young Adult -
- Find related publications in this database (Keywords)
- equestrian panniculitis
- cold panniculitis
- chilblain
- chilblain lupus erythematosus