Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Olsen, JE; Brown, NC; Eeles, AL; Einspieler, C; Lee, KJ; Thompson, DK; Anderson, PJ; Cheong, JL; Doyle, LW; Spittle, AJ.
Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born <30weeks' gestation.
Early Hum Dev. 2016; 101(39):63-68
Doi: 10.1016/j.earlhumdev.2016.06.009
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Einspieler Christa
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- Abstract:
- Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born <30weeks' gestation. Prospective cohort study. GMs (categorised as 'normal' or 'abnormal') were recorded weekly from birth to 32weeks, and at 34 and 36weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). 149 infants born <30weeks' gestation were recruited from a tertiary hospital. 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p<0.03), deep grey matter abnormality (p=0.02) and increased interhemispheric distance (p<0.02). Abnormal GMs at TEA (n=55/90) were associated with more global brain abnormality (p<0.01) and cortical grey matter abnormality (p=0.01), and decreased transcerebellar diameter (p=0.04) on concurrent brain MRI. Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain - diagnostic imaging
- Case-Control Studies -
- Developmental Disabilities - diagnosis
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- Female -
- Humans -
- Infant, Newborn -
- Infant, Premature - growth & development
- Infant, Premature - physiology
- Magnetic Resonance Imaging -
- Male -
- Movement -
- Find related publications in this database (Keywords)
- General movements
- Magnetic resonance imaging
- Preterm infant
- Neurodevelopmental assessment