Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cardoso, JC; Veraitch, O; Gianotti, R; Ferrara, G; Tomasini, CF; Singh, M; Zalaudek, I; Stefanato, CM.
"Hints" in the horn: diagnostic clues in the stratum corneum.
J Cutan Pathol. 2017; 44(3):256-278
Doi: 10.1111/cup.12839
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- Zalaudek Iris
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- Abstract:
- The stratum corneum or horny layer is the uppermost layer of the epidermis, and is mainly responsible for the skin's barrier function. In spite of its complexity at the ultrastructural and molecular level, the features accessible to visualization on conventional histology are relatively limited. Nevertheless, knowledge of subtle clues that one may observe in the stratum corneum can prove useful in a wide range of situations in dermatopathology. We herein review a selection of common and rare entities in which the horny layer may reveal significantly important hints for the diagnosis. These clues include parakeratosis and its different patterns (focal, confluent, alternating, associated with spongiosis, epidermal hyperplasia or lichenoid changes), subcorneal acantholysis, infectious organisms in the stratum corneum (including fungal, bacterial and parasitic), thickening or thinning of the stratum corneum and the presence of different kinds of pigment. Even when normal, the horny layer may prove to be useful when seen in association with severe epidermal damage, a combination of features testifying to the acute nature of the underlying pathological process. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Epidermis - pathology
- Humans -
- Skin Diseases - diagnosis
- Skin Diseases - pathology
- Find related publications in this database (Keywords)
- histopathology
- hyperkeratosis
- hypokeratosis
- parakeratosis
- stratum corneum