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SHR Neuro Cancer Cardio Lipid Metab Microb

Schwameis, R; Grimm, C; Brodowicz, T; Petru, E; Hefler-Frischmuth, K; Staudigl, C; Reinthaller, A; Heinze, G; Polterauer, S; Polterauer, M.
Gamma-glutamyltransferase as novel biomarker in patients with uterine leiomyosarcoma.
Sci Rep. 2016; 6(5):33757-33757 Doi: 10.1038/srep33757 [OPEN ACCESS]
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Co-authors Med Uni Graz: Petru Edgar
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Abstract:: Gamma-glutamyltransferase (GGT) is an established marker for proliferative/apoptotic balance and has been associated with cancer risk and prognosis. The aim of this study was to evaluate the value of pre-treatment GGT serum levels as prognostic biomarker in patients with primary uterine leiomyosarcoma (ULMS). Data of women with ULMS were extracted from a multi-center database. Pre-treatment GGT serum levels were measured and patients assigned to predefined GGT risk groups. GGT values were correlated with clinico-pathological parameters and univariate and multivariable survival analyses were performed. A total of 44 patients with ULMS were analyzed. Mean (SD) pre-therapeutic GGT serum level was 33.8 (39.8) U/L. In Figo Stage I versus II-IV mean (SD) GGT values were 28.8 (34.0) U/l and 43.5 (49.2) U/l, respectively (p = 0.25). Five-year overall survival (OS) rates in ULMS patients with normal low versus higher GGT levels were 70% and 37%, respectively (p = 0.043). Univariate and multivariable analyses revealed that higher GGT serum levels (p = 0.043, p = 0.005) and high histological grade (p = 0.029, p = 0.012) were independently associated with impaired OS, respectively. Higher pre-treatment GGT serum levels were independently associated with unfavorable prognosis in women with ULMS. Thus, GGT seems to be a useful novel biomarker in ULMS.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Biomarkers, Tumor - blood; Databases, Factual -; Disease-Free Survival -; Female -; Humans -; Leiomyosarcoma - blood; Leiomyosarcoma - mortality; Middle Aged -; Neoplasm Proteins - blood; Survival Rate -; Uterine Neoplasms - blood; Uterine Neoplasms - mortality; gamma-Glutamyltransferase - blood