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SHR Neuro Cancer Cardio Lipid Metab Microb

Speicher, MR; Gerger, A; Hoefler, G.
Liquid biopsies. A multidisciplinary challenge for human geneticists, oncologists, and pathologists
MED GENET-BERLIN. 2016; 28(2): 245-250. Doi: 10.1007/s11825-016-0090-6 [OPEN ACCESS]
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Leading authors Med Uni Graz: Speicher Michael
Co-authors Med Uni Graz: Gerger Armin; Höfler Gerald
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Abstract:: In oncology, "liquid biopsy" refers to the analysis of circulating tumor cells (CTCs) or of circulating tumor DNA (ctDNA), to establish non-invasively from the peripheral blood the characteristics of a tumor genome in cancer patients. Liquid biopsies have tremendous potential for future developments in personalized medicine and for the application of targeted therapies. In this review we show that many unresolved issues need to be addressed before liquid biopsies can be routinely used. A particular challenge is the fact that, depending on the analysis performed, the results can have implications reaching far beyond the analysis of the tumor genome originally intended. All of these issues can best be addressed in a multidisciplinary setting with human geneticists, oncologists, pathologists, bioinformaticians and bioethicists participating.
Find related publications in this database (Keywords): Circulating tumor DNA (ctDNA) analysis; Tumor diagnosis; Circulating tumor cells; Personalized medicine; Next generation sequencing (NGS) of tumor genomes