Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Margonis, GA; Amini, N; Sasaki, K; Kim, Y; Merath, K; Buettner, S; Pikoulis, E; Andreatos, N; Wagner, D; Antoniou, E; Pawlik, TM.
Perioperative Hyperglycemia and Postoperative Outcomes in Patients Undergoing Resection of Colorectal Liver Metastases.
J Gastrointest Surg. 2017; 21(2): 228-237.
Doi: 10.1007/s11605-016-3278-9
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Wagner Doris
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- Abstract:
- There is limited evidence characterizing the impact of glycemic alterations on short-term outcomes among patients undergoing resection of colorectal liver metastases (CRLM). Hyperglycemia was defined as a glucose value >125 mg/dl according to WHO definition. The impact of early postoperative hyperglycemia on short-term postoperative outcomes was assessed. The mean postoperative glucose value was 128 mg/dl; 30 (9.8 %) patients had normal fasting glucose (<100 mg/dl), 106 patients had glucose intolerance (100-125 mg/dl), and 170 (55.5 %) patients had hyperglycemia (>125 mg/dl). A postoperative complication occurred in 101 patients (morbidity, 33.1 %); among patients who experienced a complication, an infectious complication was most common (38.6 %). After controlling for clinical factors, patients with hyperglycemia had an increased risk of overall complications [odds ratio (OR) 4.11; 95 % confidence interval (CI) 1.96-8.62, P < 0.001]. This was the case for both patients with and without diabetes (P < 0.05). Patients with hyperglycemia on the day of surgery were also at an increased risk of infections [OR 9.17; 95 % CI 2.26-37.13, P = 0.002] and had a longer hospital stay (normal glucose, 4 days vs. glucose 100-125 mg/dl, 4 days vs. glucose >125 mg/dl, 5 days, P < 0.001). Early postoperative hyperglycemia was associated with adverse outcomes in patients with and without diabetes who underwent resection of CRLM. Perioperative glucose evaluation may be an important quality target.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Glucose - analysis
- Colorectal Neoplasms - blood
- Colorectal Neoplasms - pathology
- Colorectal Neoplasms - surgery
- Diabetes Mellitus - blood
- Female -
- Hepatectomy - adverse effects
- Humans -
- Hyperglycemia - blood
- Hyperglycemia - complications
- Liver Neoplasms - blood
- Liver Neoplasms - secondary
- Liver Neoplasms - surgery
- Male -
- Middle Aged -
- Perioperative Period -
- Postoperative Period -
- Retrospective Studies -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Hyperglycemia
- CRLM
- Short-term outcomes