Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dichlberger, A; Schlager, S; Kovanen, PT; Schneider, WJ.
Lipid droplets in activated mast cells - a significant source of triglyceride-derived arachidonic acid for eicosanoid production.
Eur J Pharmacol. 2016; 785(2):59-69
Doi: 10.1016/j.ejphar.2015.07.020
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schlager Stefanie
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Mast cells are potent effectors of immune reactions and key players in various inflammatory diseases such as atherosclerosis, asthma, and rheumatoid arthritis. The cellular defense response of mast cells represents a unique and powerful system, where external signals can trigger cell activation resulting in a stimulus-specific and highly coordinated release of a plethora of bioactive mediators. The arsenal of mediators encompasses preformed molecules stored in cytoplasmic secretory granules, as well as newly synthesized proteinaceous and lipid mediators. The release of mediators occurs in strict chronological order and requires proper coordination between the endomembrane system and various enzymatic machineries. For the generation of lipid mediators, cytoplasmic lipid droplets have been shown to function as a major intracellular pool of arachidonic acid, the precursor for eicosanoid biosynthesis. Recent studies have revealed that not only phospholipids in mast cell membranes, but also triglycerides in mast cell lipid droplets are a substrate source for eicosanoid formation. The present review summarizes current knowledge about mast cell lipid droplet biology, and discusses expansions and challenges of traditional mechanistic models for eicosanoid production. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arachidonic Acid - metabolism
- Eicosanoids - biosynthesis
- Humans -
- Lipid Droplets - metabolism
- Mast Cells - cytology
- Mast Cells - immunology
- Mast Cells - metabolism
- Triglycerides - metabolism
- Find related publications in this database (Keywords)
- Adipose triglyceride lipase
- Arachidonic acid
- Eicosanoids
- Lipid droplets
- Mast cells
- Triglycerides