Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lisborg, PH; Jatzko, GR; Denk, H; Klimpfinger, MH; Stettner, HM.
Long-term survival analysis of gastric cancer limited to the subserosa.
Z Gastroenterol. 1997; 35(9):663-668
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Denk Helmut
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- Abstract:
- Long-term survival following surgery for gastric cancer limited to the subserosa was analyzed. Between 01.01.1984 and 30.06.1995. 265 patients were operated for gastric cancer that did not invade beyond the subserosa. Extended lymphadenectomy was performed in all cases and was constant as all patients were operated by only two surgeons. The survival outcome was analyzed with particular regard to the exact depth of tumor infiltration and lymph node involvement. The percentage of patients with positive lymph nodes increased drastically from 1.7% for mucosal invasion to 22.7% for submucosal tumor involvement. A further substantial increase was observed from 34.3% for involvement of the muscularis propria to 66.1% for subserosal involvement. The 10-year tumor specific survival rate for tumors limited to the mucosa was 100%, for submucosa and muscularis propria invasion 79.3% and 72.9% respectively, for subserosal involvement 10-year survival was 54.6%. In multivariate analysis of pathohistological variables only pT- and pN-categories according to the UICC were found to have independent prognostic influence on survival. Long-term survival indicates that gastric cancer limited to the mucosa may well be treated with a less radical approach. Gastric cancer of the submucosa and muscularis propria both have a similar good long-term prognosis with radical surgery alone whereas cancer of the subserosa probably requires some form of adjuvant therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Female -
- Follow-Up Studies -
- Gastrectomy -
- Gastric Mucosa - pathology
- Humans - pathology
- Lymph Node Excision - pathology
- Lymphatic Metastasis - pathology
- Male - pathology
- Middle Aged - pathology
- Neoplasm Invasiveness - pathology
- Neoplasm Staging - pathology
- Postoperative Complications - mortality
- Stomach Neoplasms - mortality
- Survival Analysis - mortality
- Treatment Outcome - mortality
- Find related publications in this database (Keywords)
- Gastric Carcinoma
- Early Gastric Cancer
- Advanced Gastric Cancer
- Muscularis Propria
- Subserosa