Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, E.
Cellular elimination of nanoparticles.
Environ Toxicol Pharmacol. 2016; 46(11):90-94
Doi: 10.1016/j.etap.2016.07.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Exposure of the general population to nanoparticles (NPs) occurs mainly by dermal and oral uptake of consumer products, food and pharmaceutical applications and by inhalation. While cellular uptake mechanisms have been intensely studied it is less well known how NPs are eliminated from the cells. Quantification of the amount of excreted particles is complicated by inherent limitations of the technologies that are suitable to study excretion. Among the mechanisms to decrease intracellular particle concentration active excretion by lysosomal exocytosis appears to be the most important. Lysosomal localization, small particle size and high intracellular and low extracellular particle levels facilitate exocytosis. Transporting epithelia, cells with secretory function and highly proliferative cells are expected to be able to decrease intracellular particle concentrations more efficiently than cells lacking these characteristics. As NPs can influence the extent of exocytosis it is possible that NPs can stimulate their excretion. Copyright © 2016 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biological Transport -
- Cell Death -
- Cell Proliferation -
- Exocytosis -
- Exosomes - metabolism
- Humans -
- Lysosomes - metabolism
- Nanoparticles - metabolism
- Particle Size -
- Find related publications in this database (Keywords)
- Nanoparticles
- Toxicity
- Lysosomes
- Exosomes
- Exocytosis