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Selected Publication:
Haas, A; Uyguner, I; Sochor, GE; Schmut, O; Vidic, B; Faulborn, J.
Non-arteritic anterior ischemic optic neuropathy: long-term results after hemodilution therapy
Klin Monatsbl Augenheilkd. 1994; 205(3):143-146
Doi: 10.1055/s-2008-1045507
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Haas Anton
- Co-authors Med Uni Graz
- Schmut Otto
- Vidic Bertram
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- Abstract:
- BACKGROUND: In patients with nonarteritic anterior ischemic optic neuropathy (AION) we investigated the long-term effect of hemodilution on functional results, recurrence rate in the affected and involvement of the second eye. PATIENTS AND METHODS: In a retrospective study we reviewed 24 patients ranging in age from 62 to 92 years (mean 77 years) with AION. The duration of follow-up was between 8-51 months (mean 24.8 months). All patients received iso- (Hct > 40%) or hypervolemic (Hct < or = 40%) hemodilution over 8-10 days with daily infusion of 10% hydroxyethyl-starch 200/0.5. The hematocrit decreased significant (p < 0.001) from 43.4 +/- 3.8% to 37.8 +/- 3.5% after this 10-day hemodilution treatment. RESULTS: After the longterm follow-up 29.1% of the patients had an improvement of the central vision by two or more lines, 16.7% had a deterioration, 54.2% remained unchanged. The resulting visual acuity was between 0.5-1.0 in 37.5%, between 0.4-0.1 in 41.7% and worse than 0.1 in 20.8%. Neither visual fields nor the VECP were significant changed by hemodilution. After the mean follow-up period of 24.8 months no recurrence occurred in the affected eye and the second eye as never involved. CONCLUSION: Hemodilution therapy has no significant longterm effect on visual acuity and visual fields, but it seems to have a beneficial influence on the recurrence rate in the affected and on the involvement of the second eye.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Evoked Potentials, Visual - drug effects
- Female - drug effects
- Follow-Up Studies - drug effects
- Hematocrit - drug effects
- Hemodilution - methods
- Hetastarch - administration and dosage
- Humans - administration and dosage
- Ischemia - blood
- Long-Term Care - blood
- Male - blood
- Middle Aged - blood
- Optic Nerve - blood supply
- Optic Neuritis - blood
- Recurrence - blood
- Retrospective Studies - blood
- Visual Acuity - drug effects
- Visual Fields - drug effects
- Find related publications in this database (Keywords)
- Nonarteritic Anterior Ischemic Optic Neuropathy
- Hemodilution
- Recurrence