Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kirsch, AH; Lyko, R; Nilsson, LG; Beck, W; Amdahl, M; Lechner, P; Schneider, A; Wanner, C; Rosenkranz, AR; Krieter, DH.
Performance of hemodialysis with novel medium cut-off dialyzers.
Nephrol Dial Transplant. 2017; 32(1):165-172
Doi: 10.1093/ndt/gfw310
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Kirsch Alexander
- Co-authors Med Uni Graz
- Rosenkranz Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Compared to high-flux dialysis membranes, novel medium cut-off (MCO) membranes show greater permeability for larger middle molecules. In two prospective, open-label, controlled, randomized, crossover pilot studies, 39 prevalent hemodialysis (HD) patients were studied in four dialysis treatments as follows: study 1, three MCO prototype dialyzers (AA, BB and CC with increasing permeability) and one high-flux dialyzer in HD; and study 2, two MCO prototype dialyzers (AA and BB) in HD and high-flux dialyzers in HD and hemodiafiltration (HDF). Primary outcome was lambda free light chain (λFLC) overall clearance. Secondary outcomes included overall clearances and pre-to-post-reduction ratios of middle and small molecules, and safety of MCO HD treatments. MCO HD provided greater λFLC overall clearance [least square mean (standard error)] as follows: study 1: MCO AA 8.5 (0.54), MCO BB 11.3 (0.51), MCO CC 15.0 (0.53) versus high-flux HD 3.6 (0.51) mL/min; study 2: MCO AA 10.0 (0.58), MCO BB 12.5 (0.57) versus high-flux HD 4.4 (0.57) and HDF 6.2 (0.58) mL/min. Differences between MCO and high-flux dialyzers were consistently significant in mixed model analysis (each P < 0.001). Reduction ratios of λFLC were greater for MCO. Clearances of α1-microglobulin, complement factor D, kappa FLC (κFLC) and myoglobin were generally greater with MCO than with high-flux HD and similar to or greater than clearances with HDF. Albumin loss was moderate with MCO, but greater than with high-flux HD and HDF. MCO HD removes a wide range of middle molecules more effectively than high-flux HD and even exceeds the performance of high-volume HDF for large solutes, particularly λFLC. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Albumins - analysis
- Alpha-Globulins - analysis
- Cross-Over Studies -
- Female -
- Hemodiafiltration - methods
- Humans -
- Immunoglobulin lambda-Chains - analysis
- Male -
- Membranes, Artificial -
- Middle Aged -
- Permeability -
- Pilot Projects -
- Prospective Studies -
- Renal Dialysis - methods
- Find related publications in this database (Keywords)
- beta2-microglobulin
- dialysis
- hemodiafiltration
- hemodialysis
- uremic toxins