Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmitz, S; Unthan, K; Sedlaczek, M; Wald, F; Finocchiaro, T; Spiliopoulos, S; Koerfer, R; Steinseifer, U.
Prototype Development of an Implantable Compliance Chamber for a Total Artificial Heart.
Artif Organs. 2017; 41(2): 122-129.
Doi: 10.1111/aor.12738
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Spiliopoulos Sotirios
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- Abstract:
- At our institute a total artificial heart is being developed. It is directly actuated by a linear drive in between two ventricles, which comprise membranes to separate the drive and blood flow. A compliance chamber (CC) is needed to reduce pressure peaks in the ventricles and to increase the pump capacity. Therefore, the movement of the membrane is supported by applying a negative pressure to the air volume inside the drive unit. This study presents the development of the implantable CC which is connected to the drive unit of the total artificial hearts (TAH). The anatomical fit of the CC is optimized by analyzing CT data and adapting the outer shape to ensure a proper fit. The pressure peaks are reduced by the additional volume and the flexible membrane of the CC. The validation measurements of change in pressure peaks and flow are performed using the complete TAH system connected to a custom mock circulation loop. Using the CC, the pressure peaks could be damped below 5 mm Hg in the operational range. The flow output was increased by up to 14.8% on the systemic side and 18.2% on the pulmonary side. The described implantable device can be used for upcoming chronic animal trials. © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Heart - anatomy & histology
- Heart, Artificial -
- Hemodynamics -
- Humans -
- Prosthesis Design -
- Prosthesis Implantation -
- Thorax - anatomy & histology
- Find related publications in this database (Keywords)
- Compliance chamber
- Total artificial heart
- Implantability
- CT data analysis