Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Michaely, HJ; Aschauer, M; Deutschmann, H; Bongartz, G; Gutberlet, M; Woitek, R; Ertl-Wagner, B; Kucharczyk, W; Hammerstingl, R; De Cobelli, F; Rosenberg, M; Balzer, T; Endrikat, J.
Gadobutrol in Renally Impaired Patients: Results of the GRIP Study.
Invest Radiol. 2017; 52(1):55-60
Doi: 10.1097/RLI.0000000000000307
[OPEN ACCESS]
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Aschauer Manuela
- Deutschmann Hannes
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- Abstract:
- The aim of this study was to assess the potential risk of gadobutrol-enhanced magnetic resonance imaging (MRI) in patients with moderate to severe renal impairment for the development of nephrogenic systemic fibrosis (NSF). We performed a prospective, international, multicenter, open-label study in 55 centers. Patients with moderate to severe renal impairment scheduled for any gadobutrol-enhanced MRI were included. All patients received a single intravenous bolus injection of gadobutrol at a dose of 0.1 mmol/kg body weight. The primary target variable was the number of patients who develop NSF within a 2-year follow-up period. A total of 908 patients were enrolled, including 586 with moderate and 284 with severe renal impairment who are at highest risk for developing NSF. The mean time since renal disease diagnosis was 1.83 and 5.49 years in the moderate and severe renal impairment cohort, respectively. Overall, 184 patients (20.3%) underwent further contrast-enhanced MRI with other gadolinium-based contrast agents within the 2-year follow-up. No patient developed symptoms conclusive of NSF. No safety concerns with gadobutrol in patients with moderate to severe renal impairment were identified. There were no NSF cases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Contrast Media - administration & dosage
- Contrast Media - adverse effects
- Female -
- Humans -
- Injections, Intravenous -
- Magnetic Resonance Imaging - adverse effects
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Nephrogenic Fibrosing Dermopathy - diagnostic imaging
- Nephrogenic Fibrosing Dermopathy - etiology
- Organometallic Compounds - administration & dosage
- Organometallic Compounds - adverse effects
- Prospective Studies -
- Renal Insufficiency - complications
- Renal Insufficiency - diagnostic imaging
- Young Adult -
- Find related publications in this database (Keywords)
- gadobutrol
- renal impairment
- NSF