Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Löffler, T; Schweinzer, C; Flunkert, S; Sántha, M; Windisch, M; Steyrer, E; Hutter-Paier, B.
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice.
Mol Cell Neurosci. 2016; 74(2):34-41 Doi: 10.1016/j.mcn.2016.03.004
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Löffler Tina
Co-Autor*innen der Med Uni Graz: Schweinzer Cornelia Katrin; Steyrer Ernst
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Abstract:: Processing of the amyloid precursor protein (APP) and amyloid beta (Aβ) has been for decades in the center of Alzheimer's disease (AD) research. Beside many other variables, lipids, especially cholesterol and its derivatives, are discussed to contribute to AD pathogenesis. Several studies show that cholesterol affects APP metabolism. Also the converse mechanism, the direct influence of Aβ on cholesterol metabolism, has been described. To further investigate this crosstalk between cholesterol- and APP metabolism, a high-fat feeding study was conducted with animals overexpressing human APPSL and/or human ApoB-100. The impact of diet and genotype on cerebral cholesterol metabolism and content as well as spatial learning and memory was examined. While behavioral performance was not influenced by this high fat diet (HFD), reduction of cortical free cholesterol levels and mRNA expression patterns under normal diet and HFD conditions in human APPSL overexpressing mice argue for an important role of APP in cerebral lipid metabolism. From our results we conclude that increased APP metabolism in ApoBxAPP and APPSL mice induces mechanisms to reduce free cholesterol levels. Copyright © 2016. Published by Elsevier Inc.
Find related publications in this database (using NLM MeSH Indexing): Alzheimer Disease - blood; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals -; Apolipoprotein B-100 - genetics; Apolipoprotein B-100 - metabolism; Cerebral Cortex - metabolism; Cholesterol - blood; Cholesterol - metabolism; Diet, High-Fat - adverse effects; Dietary Fats - metabolism; Female -; Genotype -; Homeostasis -; Humans -; Male -; Maze Learning -; Mice -; Mice, Inbred C57BL -
Find related publications in this database (Keywords): Alzheimer's disease; A beta; Cholesterol; Amyloid precursor protein overexpression; Mouse model; APP(SL)