Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sunitsch, S; Gilg, M; Kashofer, K; Leithner, A; Liegl-Atzwanger, B; Beham-Schmid, C.
Case Report: Epstein-Barr-Virus negative diffuse large B-cell lymphoma detected in a peri-prosthetic membrane.
Diagn Pathol. 2016; 11(1):80-80
Doi: 10.1186/s13000-016-0533-z
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Liegl-Atzwanger Bernadette
- Sunitsch Sandra
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Gilg Magdalena Maria
- Kashofer Karl
- Leithner Andreas
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- Abstract:
- Primary bone lymphomas (PBL) are extremely rare malignant neoplasms. The most commonly described subtype of PBL is diffuse large B-cell lymphoma (DLBCL). DLBCL within peri-prosthetic membrane of a joint is exceedingly rare. To the best of our knowledge this case is the second reported Epstein-Bar-Virus (EBV) negative DLBCL in a peri-prosthetic membrane in the literature. We report an 80 year old female patient who developed a DLBCL with chronic inflammation in association to a metallic implant in the left knee. This lymphoma in contrast to the usually described DLBCL in the peri-prosthetic membrane was EBV negative by EBER in situ hybridization as well as by polymerase chain reaction (PCR). This report challenges the concept of DLBCL associated with chronic inflammation and raises the question of other pathogenetic factors involved in the pathogenesis of this rare disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged, 80 and over -
- Arthroplasty, Replacement, Knee - adverse effects
- Arthroplasty, Replacement, Knee - instrumentation
- Biomarkers, Tumor - analysis
- Biopsy -
- Chemoradiotherapy -
- Female -
- Humans -
- Immunohistochemistry -
- Knee Prosthesis -
- Lymphoma, Large B-Cell, Diffuse - chemistry
- Lymphoma, Large B-Cell, Diffuse - etiology
- Lymphoma, Large B-Cell, Diffuse - pathology
- Lymphoma, Large B-Cell, Diffuse - therapy
- Metals -
- Prosthesis Design -
- Prosthesis Failure -
- Risk Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Primary bone lymphoma
- Diffuse large B-cell lymphoma
- Epstein-Barr-Virus negative
- Knee arthroplasty
- Periprosthetic membrane