Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Chaillon, A; Mehta, SR; Smith, DM; Graff-Zivin, J; Little, SJ.
Screening for acute HIV infection in community-based settings: Cost-effectiveness and impact on transmissions.
J Infect. 2016; 73(5):476-484
Doi: 10.1016/j.jinf.2016.07.019
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- To determine cost-effectiveness of three community-based acute HIV infection (AHI) testing algorithms compared to HIV antibody testing alone by focusing on the potential of averting new infections occurring within a one-year time horizon among men who have sex with men (MSM). Data sources for model parameters included actual cost and prevalence data derived from a community-based AHI screening program in San Diego, and published studies. Main outcome measure was costs per infection averted (IA). The lower end of the cost range of discounted lifetime costs of an HIV infection (i.e. $236,948) was used for defining cost-effectiveness. The most sensitive algorithm for AHI detection, which was based on HIV nucleic acid amplification testing, was estimated to prevent between 5 and 45 transmissions, with simulated costs per infection averted between $965 and $141,256 when compared to HIV antibody testing alone. AHI testing was cost-effective in preventing new HIV infections among at risk MSM in San Diego, and also among other MSM populations with similar HIV prevalence but lower proportions of AHI diagnoses. These results indicate that community-based AHI testing among MSM in the United States can pay for itself over the long run. Copyright © 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms -
- California - epidemiology
- Cost-Benefit Analysis -
- Early Diagnosis -
- HIV Infections - diagnosis
- HIV Infections - economics
- HIV Infections - epidemiology
- HIV Infections - prevention & control
- Health Promotion - economics
- Health Promotion - methods
- Homosexuality, Male -
- Humans -
- Male -
- Monte Carlo Method -
- Preventive Health Services - economics
- Preventive Health Services - methods
- Risk Assessment -
- Safe Sex -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- HIV transmission
- Acute HIV
- MSM
- Testing
- Cost analysis
- NAT
- Infection averted