Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Saroufim, M; Novy, M; Taraif, S; Habib, RH; Loya, A; Rauscher, B; Kriegshäuser, G; Oberkanins, C; Khalifeh, I.
BRAF mutational epidemiology in dysplastic nevi: does different solar UV radiation exposure matter?
J Eur Acad Dermatol Venereol. 2014; 28(5): 615-625.
Doi: 10.1111/jdv.12148
Web of Science
PubMed
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- Kriegshäuser Gernot
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- Abstract:
- Proto-oncogene B-Raf (BRAF) mutation rates have been reported in nevi and melanomas of homogeneous Caucasian cohorts. To study the demographics of BRAF mutations in dysplastic nevi of populations with differing potential solar UV radiation exposure. Extended BRAF testing for 9 mutations in 125 dysplastic nevi from 101 patients, derived from populations with differing potential UV radiation exposure rates (Lebanon and Saudi Arabia), was performed. Clinical and microscopic parameters were recorded. BRAF mutation status was carried out for 101/125 (80.8%) cases with an overall mutation rate of 62.4% (63/101). V600E (c.1799T > A) was the predominant mutation, found in 61/63 (96.8%) cases. BRAF mutation rate differed significantly by potential UV radiation exposure (Lebanon: 53.4%, Saudi Arabia: 74.4%, P < 0.05). A 43.8% discordant mutation rate (7/16 patients) was found in patients with multiple nevi, including 2 patients with different BRAF mutations. Microscopic examination subdivided the dysplasia into mild (n = 24), moderate (n = 60) and severe (n = 41) with trunk predominance (72.8%). Higher rates of pigment in the stratum corneum were identified in Saudi Arabia (P < 0.05). No statistical significant increase in BRAF mutation rate was noted with advanced architectural and cytological atypia. Parameters associated with a negative BRAF mutation status included upper extremity location, regression, cohesiveness and presence of suprabasal melanocytes (P < 0.05). Positive BRAF mutation status was reasonably predicted by multivariate binary logistic regression by 2 independent predictors: Geographic location and compound nevus type. In our Near Eastern cohort, the BRAF mutation rate varied significantly by geographic location. In patients with multiple dysplastic nevi examined, discordant BRAF mutation status potentially negates an underlying constitutional predilection. © 2013 The Authors Journal of the European Academy of Dermatology and Venereology © 2013 European Academy of Dermatology and Venereology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Dysplastic Nevus Syndrome - epidemiology Dysplastic Nevus Syndrome - genetics
- Female -
- Humans -
- Male -
- Molecular Epidemiology -
- Mutation -
- Occupational Exposure -
- Proto-Oncogene Proteins B-raf - genetics
- Sunlight -