Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Löhr, M; Tzouras, G; Molcanyi, M; Ernestus, RI; Hampl, JA; Fischer, JH; Sahin, K; Arendt, T; Härtig, W.
Degeneration of cholinergic rat basal forebrain neurons after experimental subarachnoid hemorrhage.
Neurosurgery. 2008; 63(2): 336-344.
Doi: 10.1227/01.NEU.0000320422.54985.6D
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Molcanyi Marek
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- Abstract:
- The reasons for neuropsychological deficits after subarachnoid hemorrhage (SAH) are fairly unknown. Cholinergic basal forebrain (BFB) neurons are essential for attention, memory, and emotion. We investigated possible changes in the cholinergic BFB and its hippocampal and neocortical terminals after experimental SAH. SAH was induced in 19 male Wistar rats by stereotactic injection of 150 microL of autologous blood into the prechiasmatic cistern. Five control animals received 150 microL of saline. Continuous monitoring of brain tissue oxygen tension, intracranial pressure, and cerebral perfusion pressure was performed. After 4 and 14 days, the BFB was analyzed for cholinergic and gamma-aminobutyric acid-ergic cell counts. The number of cholinergic terminals in the hippocampus and neocortex was calculated by optical densitometry. SAH resulted in a 20 to 30% decrease in cholinergic BFB neurons in the medial septum and diagonal band at 4 and 14 days. A similar decline in the density of hippocampal and neocortical cholinergic terminals was demonstrated. Animals treated with saline did not exhibit significant cholinergic cell loss, and gamma-aminobutyric acid-ergic neurons appeared unaffected by the SAH. Courses of intracranial pressure and cerebral perfusion pressure did not differ between animals injected with blood and saline, but brain tissue oxygen tension decreased considerably and continued to stay below baseline in SAH, although it returned to normal values after saline injection. The present study provides evidence for a decrease of cholinergic BFB neurons after SAH. The direct effect of blood in the basal cisterns seemed to result in an enduring tissue hypoxia as a significant mechanism for cholinergic degeneration.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholinergic Fibers - pathology
- Male -
- Nerve Degeneration - etiology Nerve Degeneration - pathology Nerve Degeneration - physiopathology
- Neurons - pathology
- Prosencephalon - pathology Prosencephalon - physiopathology
- Rats -
- Rats, Wistar -
- Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology
- Find related publications in this database (Keywords)
- basal forebrain
- cholinergic degeneration
- hypoxia
- neuropsychological deficits
- subarachnoid hemorrhage